Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers.
Normative Pancreatic Stiffness Levels and Related Influences Established by Magnetic Resonance Elastography in Volunteers.
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磁共振弹性成像在志愿者中建立的规范性胰腺僵硬水平及相关影响
DOI：
10.1002/jmri.27052
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Chang Liu
中科院分区：
文献类型：
--
作者：
Xu Y;Cai X;Shi Y;Yin M;Lan G;Zhang X;Ji R;Chang Liu
对胰腺僵硬及其潜在影响的大规模标准化研究尚未通过磁共振弹性成像(MRE)进行。确定标准的基于MRE的胰腺刚度值，并检查相关影响因素。有远见。总共招募了361名志愿者(男性199名，女性162名)，年龄中位数为54.0岁，体重指数(BMI)中位数为22.86公斤/平方米。那些没有吸烟、酗酒和糖尿病(DM)病史的人被归类为健康志愿者，其他人都被指定为阳性对照。每个志愿者都接受了3.0T频率为40赫兹的胰腺MRI。测量所有受试者的胰腺硬挺值、胰腺宽度和体积、腰围和波距。进行多元线性回归分析，以确定影响MRE确定的硬度的变量。所有受试者的平均胰腺硬度为1.20±0.16kPa.阳性对照组的僵硬水平显著高于健康志愿者(1.29±0.17kPavs.1.14±0.13kpa；P<；0.001)。多元线性回归分析显示，性别(P=0.004)、体重指数(P<；0.001)、胰腺宽度(P=0.005)、吸烟(P<；0.001)、酗酒(P<；0.001)和糖尿病(P=0.001)是影响胰腺僵硬的显著独立因素。吸烟、酗酒、糖尿病和胰腺过宽与胰腺硬度增加相关(系数分别为0.202、0.183、0.149和0.160)，而胰腺硬度降低与女性和较大的体重指数相关(系数分别为−0.155和−0.192)。基于MRE的胰腺硬度值受性别、BMI、胰腺宽度、吸烟、酗酒和糖尿病的影响。参考值对未来的临床研究是必不可少的。1阶段2
Large-scale normative studies of pancreatic stiffness and potential influences have yet to be pursued via magnetic resonance elastography (MRE). To determine normative MRE-based pancreatic stiffness values and to examine related influential factors. Prospective. In all, 361 volunteers (men, 199; women, 162) with a median age of 54.0 years and a median body mass index (BMI) of 22.86 kg/m2 were prospectively recruited. Those with no histories of smoking, alcohol abuse, and diabetes mellitus (DM) were grouped as healthy volunteers, designating all others as positive controls. Each volunteer underwent 3.0T pancreatic MRI at a frequency of 40 Hz. Pancreatic stiffness values, pancreatic width and volume, waist circumference, and wave distance were measured in all subjects. Multiple linear regression analyses were performed to determine variables that influence MRE-determined stiffness. The mean pancreatic stiffness in all volunteers was 1.20 ± 0.16 kPa. Stiffness levels in positive control volunteers proved significantly greater than levels in healthy volunteers (1.29 ± 0.17 kPa vs. 1.14 ± 0.13 kPa; P < 0.001). In multiple linear regression analysis, sex (P = 0.004), BMI (P < 0.001), pancreatic width (P = 0.005), smoking (P < 0.001), alcohol abuse (P < 0.001), and DM (P = 0.001) emerged as significant independent factors impacting pancreatic stiffness. Smoking, alcohol abuse, DM, and wide pancreas were associated with greater pancreatic stiffness (coefficients = 0.202, 0.183, 0.149, and 0.160, respectively), while reduced pancreatic stiffness corresponded with female sex and larger BMI (coefficient = −0.155 and −0.192, respectively). MRE-based pancreatic stiffness values are impacted by sex, BMI, pancreatic width, smoking, alcohol abuse, and DM. Reference values are essential for future clinical studies. 1 Stage 2
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