Capturing the complexity of autism: Applying a developmental cascades framework.
Capturing the complexity of autism: Applying a developmental cascades framework.
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DOI:
10.1111/cdep.12439
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发表时间:
2022-03
影响因子:
6.4
通讯作者:
Iverson, Jana M.
中科院分区:
文献类型:
--
作者:
Bradshaw, Jessica;Schwichtenberg, Amy J.;Iverson, Jana M.
Developmental change emerges from dynamic interactions among networks of neural activity, behavior systems, and experience-dependent processes. A developmental cascades framework captures the sequential, multilevel, cross-domain nature of human development and is ideal for demonstrating how interconnected systems have far-reaching effects in typical and atypical development. Neurodevelopmental disorders represent an intriguing application of this framework. Autism spectrum disorder (ASD) is complex and heterogeneous, with biological and behavioral features that cut across multiple developmental domains, including those that are motor, cognitive, sensory, and bioregulatory. Mapping developmental cascades in ASD can be transformational in elucidating how seemingly unrelated behaviors (e.g., those emerging at different points in development and occurring in multiple domains) are part of an interconnected neurodevelopmental pathway. In this article, we review evidence for specific developmental cascades implicated in ASD and suggest that theoretical and empirical advances in etiology and change mechanisms can be accelerated using a developmental cascades framework.
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影响因子:
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作者:
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通讯作者:
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DOI:
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期刊:
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通讯作者:
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