Capturing the complexity of autism: Applying a developmental cascades framework.

Capturing the complexity of autism: Applying a developmental cascades framework.
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DOI:
10.1111/cdep.12439
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发表时间:
2022-03
影响因子:
6.4
通讯作者:
Iverson, Jana M.
Iverson, Jana M.
中科院分区:
心理学1区
文献类型:
--
作者:
Bradshaw, Jessica;Schwichtenberg, Amy J.;Iverson, Jana M.

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发展变化来自神经活动网络、行为系统和经验依赖过程之间的动态相互作用。一个发展级联框架捕捉人类发展的顺序,多层次,跨领域的性质,是理想的展示互联系统如何在典型和非典型的发展具有深远的影响。神经发育障碍代表了这一框架的一个有趣的应用。自闭症谱系障碍(ASD)是复杂和异质性的,具有跨越多个发育领域的生物和行为特征,包括运动,认知,感觉和生物调节。绘制ASD中的发育级联反应可以在阐明看似不相关的行为(例如,在发育的不同阶段出现并在多个领域发生的那些)是相互关联的神经发育途径的一部分。在这篇文章中,我们回顾了与ASD有关的特定发育级联的证据,并建议使用发育级联框架可以加速病因学和变化机制的理论和经验进展。
Developmental change emerges from dynamic interactions among networks of neural activity, behavior systems, and experience-dependent processes. A developmental cascades framework captures the sequential, multilevel, cross-domain nature of human development and is ideal for demonstrating how interconnected systems have far-reaching effects in typical and atypical development. Neurodevelopmental disorders represent an intriguing application of this framework. Autism spectrum disorder (ASD) is complex and heterogeneous, with biological and behavioral features that cut across multiple developmental domains, including those that are motor, cognitive, sensory, and bioregulatory. Mapping developmental cascades in ASD can be transformational in elucidating how seemingly unrelated behaviors (e.g., those emerging at different points in development and occurring in multiple domains) are part of an interconnected neurodevelopmental pathway. In this article, we review evidence for specific developmental cascades implicated in ASD and suggest that theoretical and empirical advances in etiology and change mechanisms can be accelerated using a developmental cascades framework.
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