SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021.

SARS-CoV-2 Seroprevalence in a Rural and Urban Household Cohort during First and Second Waves of Infections, South Africa, July 2020-March 2021.
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DOI:
10.3201/eid2712.211465
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发表时间:
2021-12
影响因子:
11.8
通讯作者:
PHIRST-C Group
PHIRST-C Group
中科院分区:
医学2区
文献类型:
--
作者:
Kleynhans J;Tempia S;Wolter N;von Gottberg A;Bhiman JN;Buys A;Moyes J;McMorrow ML;Kahn K;Gómez-Olivé FX;Tollman S;Martinson NA;Wafawanaka F;Lebina L;du Toit J;Jassat W;Neti M;Brauer M;Cohen C;PHIRST-C Group

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严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染可能被低估,因为获得检测的机会有限。我们在2020年7月至2021年3月期间每2个月在南非2个社区随机选择的家庭队列中测量SARS-CoV-2血清阳性率。我们将血清阳性率与报告的实验室确认的感染、住院和死亡进行比较,以计算2波感染中的感染-病例、感染-住院和感染-死亡比率。第二波后血清阳性率从农村社区5岁以下儿童的18%到城市社区35-59岁成人的59%不等。在第二波中,城市社区的病例-病人的年龄分布发生了变化(从35-59岁的人到年龄极端的人),农村社区的发病率较高,城市社区的感染-死亡率较高。大约95%的SARS-CoV-2感染没有向国家监测报告。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections may be underestimated because of limited access to testing. We measured SARS-CoV-2 seroprevalence in South Africa every 2 months during July 2020–March 2021 in randomly selected household cohorts in 2 communities. We compared seroprevalence to reported laboratory-confirmed infections, hospitalizations, and deaths to calculate infection–case, infection–hospitalization, and infection–fatality ratios in 2 waves of infection. Post–second wave seroprevalence ranged from 18% in the rural community children <5 years of age, to 59% in urban community adults 35–59 years of age. The second wave saw a shift in age distribution of case-patients in the urban community (from persons 35–59 years of age to persons at the extremes of age), higher attack rates in the rural community, and a higher infection–fatality ratio in the urban community. Approximately 95% of SARS-CoV-2 infections were not reported to national surveillance.
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发表时间: 2021-09
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Jassat W;Mudara C;Ozougwu L;Tempia S;Blumberg L;Davies MA;Pillay Y;Carter T;Morewane R;Wolmarans M;von Gottberg A;Bhiman JN;Walaza S;Cohen C;DATCOV author group
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影响因子: 4.4
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