Diffusion spectrum imaging of patients with middle cerebral artery stenosis.
Diffusion spectrum imaging of patients with middle cerebral artery stenosis.
复制标题
大脑中动脉狭窄患者的弥散谱成像
DOI：
10.1016/j.nicl.2022.103133
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发表时间：
2022
影响因子：
4.2
通讯作者：
Liu, Zhenghua
中科院分区：
文献类型：
--
作者：
Wan, Xinghua;Xiao, Yu;Liu, Zhenghua
关键词：
扩散谱成像（DSI）显示，单侧大脑中动脉（MCA）狭窄患者的结构网络遭到破坏。
无中风的单侧MCA狭窄患者存在白质纤维损伤。
MCA狭窄患者病灶半球的纤维破坏更为严重。
DSI技术是一种可应用于临床研究的无创且敏感的工具。
我们旨在利用扩散谱成像（DSI）检测单侧大脑中动脉（MCA）狭窄患者大脑的微观结构变化，并评估纤维结构和小世界网络的完整性。
共有21名健康对照者和48名单侧MCA狭窄患者采用DSI技术接受了3.0T磁共振成像（MRI）检查。使用DSI软件进行差异纤维束成像、扩散连接测量和结构网络分析。在相关性纤维束成像中，运用多元回归模型分析狭窄程度与定量各向异性（QA）之间的相关性。
差异纤维束成像分析显示，与对照组相比，左侧或右侧MCA狭窄组脑网络中的纤维连接性降低。对MCA狭窄患者的相关性纤维束成像分析表明，在双侧弓状束、双侧皮质纹状体和皮质丘脑通路、双侧皮质脑桥束和皮质脊髓束、右侧上纵束、右侧扣带、胼胝体以及左侧额斜束中，QA与狭窄程度呈负相关。MCA狭窄组与对照组在图密度、全局效率、网络路径长度和富人俱乐部系数方面存在统计学显著差异。
DSI显示，无中风的单侧MCA狭窄患者存在结构网络破坏和白质纤维损伤。此外，单侧MCA狭窄患者同侧半球的纤维连接破坏更为严重，而对侧半球则不太明显。因此，即使在亚临床阶段，单侧MCA狭窄患者也已出现微观结构损伤。
DSI revealed that patients with unilateral MCA stenosis have a disrupted structural network. Stroke-free patients with unilateral MCA stenosis have damaged white matter fibers. The fiber disruption is more severe in the lesion hemisphere of patients with MCA stenosis. The DSI technique is a noninvasive and sensitive tool that can be applied in clinical research. We aimed to detect microstructural changes in the brains of patients with unilateral middle cerebral artery (MCA) stenosis and to assess the integrity of the fiber structure and the small-world networks using diffusion spectrum imaging (DSI). A total of 21 healthy controls and 48 patients with unilateral MCA stenosis underwent 3.0 T MRI examination using DSI technique. Differential tractography, diffusion connectometry, and structural networks were performed by using DSI software. The correlation between the stenosis and quantitative anisotropy (QA) were analyzed using multiple regression models in the correlation tractography. Differential tractography analysis showed that the left or right MCA stenosis group had decreased fiber connectivity in the brain network compared with the control group. The correlation tractography analysis of the patients with MCA stenosis showed that QA was negatively correlated with stenosis in the bilateral arcuate fasciculus, bilateral corticostriatal and corticothalamic pathway, bilateral corticopontine and corticospinal tract, right superior longitudinal fasciculus, right cingulum, corpus callosum, and left frontal aslant tract. Statistically significant differences were shown between the MCA stenosis groups and control group in graph density, global efficiency, network path length, and rich club coefficient. DSI revealed that stroke-free patients with unilateral MCA stenosis have a disrupted structural network and damaged white matter fibers. Furthermore, the fiber connection disruption is more severe in the ipsilateral hemisphere and less prominent in the contralateral hemisphere in patients with unilateral MCA stenosis. Therefore, microstructural impairment has happened to patients with unilateral MCA stenosis even at a subclinical stage.
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影响因子：
4.8
作者：
Mayo, Chantel D.;Garcia-Barrera, Mauricio A.;Gawryluk, Jodie R.
通讯作者：
Gawryluk, Jodie R.
影响因子：
3.2
作者：
Bigham, Bahare;Zamanpour, Seyed Amir;Zare, Hoda
通讯作者：
Zare, Hoda
影响因子：
4.8
作者：
Daianu M;Mezher A;Mendez MF;Jahanshad N;Jimenez EE;Thompson PM
通讯作者：
Thompson PM
影响因子：
5.7
作者：
Yeh, Fang-Cheng;Wedeen, Van Jay;Tseng, Wen-Yih Isaac
通讯作者：
Tseng, Wen-Yih Isaac
DOI：
10.1523/jneurosci.2308-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gong G;Rosa-Neto P;Carbonell F;Chen ZJ;He Y;Evans AC
通讯作者：
Evans AC