Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective.
Defining vitamin D status using multi-metabolite mathematical modelling: A pregnancy perspective.
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DOI：
10.1016/j.jsbmb.2019.03.024
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发表时间：
2019-06
期刊：
影响因子：
--
通讯作者：
Tamblyn JA
中科院分区：
文献类型：
--
作者：
Beentjes CHL;Taylor-King JP;Bayani A;Davis CN;Dunster JL;Jabbari S;Mirams GR;Jenkinson C;Kilby MD;Hewison M;Tamblyn JA
维生素D缺乏与不良妊娠结局（例如先兆子痫（PET））有关，但仍然通过单独测量血清25-羟基维生素D3（25（OH）D3）来定义。为了确定正常和PET妊娠期间维生素D代谢的更广泛变化，我们开发了一个相对简单但完全参数化的维生素D代谢途径数学模型。用于参数化的数据是针对女性横截面组（n = 88）分析的血清维生素D代谢物;包括在第1（NP 1，n = 25）和第3（NP 3，n = 21）的正常妊娠女性和具有PET的妊娠女性（n = 22），以及非妊娠女性对照（n = 20）。为了解释各种代谢物相互之间的影响，使用维生素D反应网络的常微分方程模型分析数据。从模型中获得的信息，然后也适用于血清维生素D代谢组数据（n = 50），从妊娠第二个三个月的队列，其中25个前瞻性开发PET。单独数据的统计分析显示，NP 3和PET之间血清25（OH）D3和24，25（OH）2D 3浓度无显著差异。相反，由反应网络模型提供的统计分析显示，PET的一个更好的指标是怀孕后期维生素D代谢物的比例。评估潜在的预测价值，NP 3和PET的情况下，在妊娠15周之间没有显着差异被发现。数学建模提供了一种新的策略，定义维生素D代谢对人类健康的影响。这在怀孕的背景下尤其相关，其中维生素D代谢的主要变化发生在整个怀孕期间，并且代谢失调在患有PET的女性中得到证实。
Vitamin D deficiency is linked to adverse pregnancy outcomes such as pre-eclampsia (PET) but remains defined by serum measurement of 25-hydroxyvitamin D3 (25(OH)D3) alone. To identify broader changes in vitamin D metabolism during normal and PET pregnancies we developed a relatively simple but fully parametrised mathematical model of the vitamin D metabolic pathway. The data used for parametrisation were serum vitamin D metabolites analysed for a cross-sectional group of women (n = 88); including normal pregnant women at 1 st (NP1, n = 25) and 3rd trimester (NP3, n = 21) and pregnant women with PET (n = 22), as well as non-pregnant female controls (n = 20). To account for the effects various metabolites have upon each other, data were analysed using an ordinary differential equation model of the vitamin D reaction network. Information obtained from the model was then also applied to serum vitamin D metabolome data (n = 50) obtained from a 2nd trimester pregnancy cohort, of which 25 prospectively developed PET. Statistical analysis of the data alone showed no significant difference between NP3 and PET for serum 25(OH) D3 and 24,25(OH)2D3 concentrations. Conversely, a statistical analysis informed by the reaction network model revealed that a better indicator of PET is the ratios of vitamin D metabolites in late pregnancy. Assessing the potential predicative value, no significant difference between NP3 and PET cases at 15 weeks gestation was found. Mathematical modelling offers a novel strategy for defining the impact of vitamin D metabolism on human health. This is particularly relevant within the context of pregnancy, where major changes in vitamin D metabolism occur across gestation, and dysregulated metabolism is evidenced in women with established PET.
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影响因子：
2.9
作者：
Tamblyn JA;Jenkinson C;Larner DP;Hewison M;Kilby MD
通讯作者：
Kilby MD
影响因子：
3.6
作者：
Jones, Kerry S.;Schoenmakers, Inez;Bluck, Les J. C.;Ding, Shujing;Prentice, Ann
通讯作者：
Prentice, Ann
影响因子：
5.8
作者：
Hansen, Lasse Bollehuus;Rehfeld, Anders;Jensen, Martin Blomberg
通讯作者：
Jensen, Martin Blomberg
影响因子：
4.2
作者：
Bodnar, Lisa M.;Catov, Janet M.;Simhan, Hyagriv N.
通讯作者：
Simhan, Hyagriv N.
影响因子：
3.9
作者：
Hyppoenen, Elina
通讯作者：
Hyppoenen, Elina