Smoking and the risk of type 2 diabetes in Japan: A systematic review and meta-analysis.
Smoking and the risk of type 2 diabetes in Japan: A systematic review and meta-analysis.
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DOI：
10.1016/j.je.2016.12.017
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发表时间：
2017-12
影响因子：
4.7
通讯作者：
Mizoue T
中科院分区：
文献类型：
--
作者：
Akter S;Goto A;Mizoue T
吸烟是导致疾病负担的主要可避免原因。观察性研究表明，吸烟与2型糖尿病（T2 DM）风险之间存在关联。我们对前瞻性观察性研究进行了荟萃分析，以调查日本吸烟状况、吸烟强度和戒烟与T2 DM风险的相关性，日本的吸烟率一直在下降，但仍然很高。我们系统性检索了MEDLINE和Ichushi数据库，检索时间截止至2015年12月，共识别出22篇合格文章，代表343，573例受试者和16，383例T2 DM患者。我们使用随机效应模型估计合并相对风险（RR），并按受试者和研究特征进行亚组分析。与不吸烟者相比，目前吸烟（19项研究）的T2 DM合并RR为1.38（95%置信区间[CI]，1.28-1.49），既往吸烟（15项研究）的合并RR为1.19（95% CI，1.09-1.31）。这些关联在所有亚组和敏感性分析中持续存在。我们发现吸烟量与T2 DM风险之间存在线性剂量反应关系;每天吸烟10支，T2 DM风险增加16%。在戒烟前5年内戒烟的人中，T2 DM的风险仍然很高，但随着戒烟时间的增加而稳步下降，戒烟10年后达到与从不吸烟者相当的风险水平。我们估计18.8%的男性T2 DM病例和5.4%的女性T2 DM病例可归因于吸烟。目前的研究结果表明，吸烟与T2 DM的风险增加有关，因此，减少吸烟的烟草控制计划可能对减轻日本T2 DM的负担产生重大影响。这项荟萃分析研究了日本人的吸烟和糖尿病风险。目前和以前的吸烟者患糖尿病的风险高于不吸烟者。糖尿病风险随着吸烟量的增加而线性增加。戒烟后糖尿病风险稳步下降。
Cigarette smoking is the leading avoidable cause of disease burden. Observational studies have suggested an association between smoking and risk of type 2 diabetes mellitus (T2DM). We conducted a meta-analysis of prospective observational studies to investigate the association of smoking status, smoking intensity, and smoking cessation with the risk of T2DM in Japan, where the prevalence of smoking has been decreasing but remains high. We systematically searched MEDLINE and the Ichushi database to December 2015 and identified 22 eligible articles, representing 343,573 subjects and 16,383 patients with T2DM. We estimated pooled relative risks (RRs) using a random-effects model and conducted subgroup analyses by participant and study characteristics. Compared with nonsmoking, the pooled RR of T2DM was 1.38 (95% confidence interval [CI], 1.28–1.49) for current smoking (19 studies) and 1.19 (95% CI, 1.09–1.31) for former smoking (15 studies). These associations persisted in all subgroup and sensitivity analyses. We found a linear dose-response relationship between cigarette consumption and T2DM risk; the risk of T2DM increased by 16% for each increment of 10 cigarettes smoked per day. The risk of T2DM remained high among those who quit during the preceding 5 years but decreased steadily with increasing duration of cessation, reaching a risk level comparable to that of never smokers after 10 years of smoking cessation. We estimated that 18.8% of T2DM cases in men and 5.4% of T2DM cases in women were attributable to smoking. The present findings suggest that cigarette smoking is associated with an increased risk of T2DM, so tobacco control programs to reduce smoking could have a substantial effect to decrease the burden of T2DM in Japan. This meta-analysis examined smoking and diabetes risk among Japanese. Current and former smokers showed a higher risk of diabetes than non-smokers. Diabetes risk linearly increased with higher consumption of cigarettes. Diabetes risk steadily decreased after smoking cessation.
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影响因子：
3.2
作者：
Charvat H;Goto A;Goto M;Inoue M;Heianza Y;Arase Y;Sone H;Nakagami T;Song X;Qiao Q;Tuomilehto J;Tsugane S;Noda M;Inoue M
通讯作者：
Inoue M
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
11.1
作者：
ATTVALL, S;FOWELIN, J;SMITH, U
通讯作者：
SMITH, U
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
5.4
作者：
BERLIN, JA;LONGNECKER, MP;GREENLAND, S
通讯作者：
GREENLAND, S