Evolving antibiotic resistance in Group B Streptococci causing invasive infant disease: 1970-2021.
Evolving antibiotic resistance in Group B Streptococci causing invasive infant disease: 1970-2021.
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DOI：
10.1038/s41390-022-02375-3
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发表时间：
2023-06
影响因子：
3.6
通讯作者：
Flores, Anthony R.
中科院分区：
文献类型：
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作者：
Sabroske, Elizabeth Marie;Iglesias, Misu Ailin Sanson;Rench, Marcia;Moore, Trevor;Harvey, Hanna;Edwards, Morven;Baker, Carol J.;Flores, Anthony R.
我们试图确定来自婴儿早发性疾病（EOD）、晚发性疾病（LOD）和晚发性疾病（LLOD）的侵袭性GBS分离株的抗生素耐药频率。一项针对1970-2021年出生的从血液、脑脊液、滑液、蜂窝织炎或骨骼中分离出GBS的婴儿的多中心回顾性研究。采用纸片扩散法对所有分离株进行血清分型和药敏试验。2017年分离株中最常见的血清型为III型（n=1112, 55.1%）、Ia型（n=445, 22%）、Ib型（n=182, 9%）和II型（n=146, 7.2%）。婴幼儿EOD 945株（46.8%），LOD 976株（48.3%），LLOD 96株（4.75%）。所有分离株均对青霉素敏感。与分离株< 2000的菌株相比，分离株≥2000的菌株对红霉素（4.0% ~ 32.3%，P<0.0001）和克林霉素（1.5% ~ 17.5%，P<0.0001）的耐药频率显著高于分离株。分离年份（≥2000年）和血清V型与红霉素和/或克林霉素耐药显著相关。我们记录了克林霉素和红霉素耐药性的快速和显著增加。由于克林霉素可能被认为对严重青霉素过敏的妇女需要产时预防，产科医生、儿科医生和新生儿医生应该意识到这一令人不安的趋势。
We sought to define the frequency of antibiotic resistance over time in a collection of invasive GBS isolates derived from infant early onset disease (EOD), late onset disease (LOD), and late-late onset disease (LLOD). A multicenter retrospective review of infants born from 1970–2021 with GBS isolated from blood, cerebrospinal fluid, synovial fluid, cellulitis, or bone. All isolates were serotyped and antimicrobial susceptibility testing performed using disk diffusion. The most common serotypes in our 2017 isolates were III (n=1112, 55.1%), Ia (n=445, 22%), Ib (n=182, 9%) and II (n=146, 7.2%). A total of 945 (46.8%) isolates were from infants with EOD, 976 (48.3%) from LOD and 96 (4.75%) from LLOD. All isolates were penicillin susceptible. Compared to strains isolated < 2000, strains isolated ≥ 2000 showed significantly greater frequency of erythromycin (4.0% to 32.3%, P<0.0001) and clindamycin (1.5% to 17.5%, P<0.0001) resistance. Year of isolation (≥ 2000) and serotype V were significantly associated with erythromycin and/or clindamycin resistance. We document a rapid and significant increase in clindamycin and erythromycin resistance. As clindamycin may be considered in severely penicillin-allergic women needing GBS intrapartum prophylaxis, obstetricians, pediatricians and neonatologist should be aware of this disturbing trend.
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影响因子：
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作者：
Castor, Mei L;Whitney, Cynthia G;Como-Sabetti, Kathryn;Facklam, Richard R;Ferrieri, Patricia;Bartkus, Joanne M;Juni, Billie A;Cieslak, Paul R;Farley, Monica M;Dumas, Nellie B;Schrag, Stephanie J;Lynfield, Ruth
通讯作者：
Lynfield, Ruth
DOI：
10.1093/cid/cix656
发表时间：
2017-11-06
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Madrid L;Seale AC;Kohli-Lynch M;Edmond KM;Lawn JE;Heath PT;Madhi SA;Baker CJ;Bartlett L;Cutland C;Gravett MG;Ip M;Le Doare K;Rubens CE;Saha SK;Sobanjo-Ter Meulen A;Vekemans J;Schrag S;Infant GBS Disease Investigator Group
通讯作者：
Infant GBS Disease Investigator Group
影响因子：
7.7
作者：
Olesen, Scott W.;Barnett, Michael L.;Grad, Yonatan H.
通讯作者：
Grad, Yonatan H.
DOI：
10.1111/j.1368-5031.2005.00395.x
发表时间：
2005-04-01
影响因子：
2.6
作者：
Kadanali, A;Altoparlak, Ü;Kadanali, S
通讯作者：
Kadanali, S
新生儿早发病原体之间的抗菌敏感性谱。
DOI：
10.1097/inf.0000000000003380
发表时间：
2022-03-01
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Flannery DD;Puopolo KM;Hansen NI;Gerber JS;Sánchez PJ;Stoll BJ;for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
通讯作者：
for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network