Foamy-like endogenous retroviruses are extensive and abundant in teleosts.
Foamy-like endogenous retroviruses are extensive and abundant in teleosts.
复制标题
DOI：
10.1093/ve/vew032
复制
发表时间：
2016-07
期刊：
影响因子：
5.3
通讯作者：
Worobey M
中科院分区：
文献类型：
--
作者：
Ruboyianes R;Worobey M
最近的发现表明，泡沫病毒（Spumavirus）的祖先可能是脊椎动物进化过程中最早出现的逆转录病毒之一，泡沫内源性逆转录病毒存在于包括哺乳动物、腔棘鱼和鳐鱼在内的深度分化宿主中。如果它们确实存在于数亿年前的古代海洋环境中，那么鱼类基因组中可能存在大量未被发现的泡沫状内源性逆转录病毒的多样性。通过筛选已发表的基因组和应用基于pcr的保存组织分析，我们在硬骨鱼宿主中发现了23种新的泡沫样元素。这些病毒与肉翅类宿主FV形成一个强大的、相互单系的姐妹分支，第三类哺乳动物内源性逆转录病毒是这两个分支的姐妹群。其中一些泡沫状逆转录病毒的基因组比任何已知的逆转录病毒都要大，无论是外源性的还是内源性的，因为它们有异常长的gag样基因和许多辅助基因。哺乳动物FV和这些新型逆转录病毒之间保守的遗传特征的存在证明了一种保存了数亿年的泡沫状复制生物学。我们估计其中一些病毒最近才整合到宿主基因组中；这些病毒的外源形式可能仍在传播。
Recent discoveries indicate that the foamy virus (FV) (Spumavirus) ancestor may have been among the first retroviruses to appear during the evolution of vertebrates, demonstrated by foamy endogenous retroviruses present within deeply divergent hosts including mammals, coelacanth, and ray-finned fish. If they indeed existed in ancient marine environments hundreds of millions of years ago, significant undiscovered diversity of foamy-like endogenous retroviruses might be present in fish genomes. By screening published genomes and by applying PCR-based assays of preserved tissues, we discovered 23 novel foamy-like elements in teleost hosts. These viruses form a robust, reciprocally monophyletic sister clade with sarcopterygian host FV, with class III mammal endogenous retroviruses being the sister group to both clades. Some of these foamy-like retroviruses have larger genomes than any known retrovirus, exogenous or endogenous, due to unusually long gag-like genes and numerous accessory genes. The presence of genetic features conserved between mammalian FV and these novel retroviruses attests to a foamy-like replication biology conserved for hundreds of millions of years. We estimate that some of these viruses integrated recently into host genomes; exogenous forms of these viruses may still circulate.
登录
查看更多内容
影响因子：
3.8
作者：
Cui, Jie;Tachedjian, Gilda;Wang, Lin-Fa
通讯作者：
Wang, Lin-Fa
影响因子：
14.9
作者：
Finn RD;Clements J;Arndt W;Miller BL;Wheeler TJ;Schreiber F;Bateman A;Eddy SR
通讯作者：
Eddy SR
DOI：
10.1093/bioinformatics/btp348
发表时间：
2009-08-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Capella-Gutiérrez S;Silla-Martínez JM;Gabaldón T
通讯作者：
Gabaldón T
影响因子：
3.3
作者：
Delelis O;Petit C;Leh H;Mbemba G;Mouscadet JF;Sonigo P
通讯作者：
Sonigo P
DOI：
10.1371/currents.tol.53ba26640df0ccaee75bb165c8c26288
发表时间：
2013-01-01
期刊：
PLOS CURRENTS-TREE OF LIFE
影响因子：
--
作者：
Betancur-R, Ricardo;Broughton, Richard E.;Orti, Guillermo
通讯作者：
Orti, Guillermo