Response inhibition among early adolescents prenatally exposed to tobacco: an fMRI study.
Response inhibition among early adolescents prenatally exposed to tobacco: an fMRI study.
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DOI：
10.1016/j.ntt.2009.03.003
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发表时间：
2009-09
影响因子：
2.9
通讯作者：
Lewis, Michael
中科院分区：
文献类型：
--
作者：
Bennett, David S.;Mohamed, Feroze B.;Carmody, Dennis P.;Bendersky, Margaret;Patel, Sunil;Khorrami, Maryam;Faro, Scott H.;Lewis, Michael
关键词：
Children prenatally exposed to tobacco have been found to exhibit increased rates of behavior problems related to response inhibition deficits. The present study compared the brain function of tobacco-exposed (n = 7) and unexposed (n = 11) 12-year-olds during a Go/No-Go response inhibition task using an event-related functional MRI (fMRI) design. Prenatal alcohol exposure, neonatal medical problems, environmental risk, IQ, current environmental smoke exposure, and handedness were statistically controlled. Tobacco-exposed children showed greater activation in a relatively large and diverse set of regions, including left frontal, right occipital, and bilateral temporal, and parietal regions. In contrast, unexposed but not exposed children showed activation in the cerebellum, which prior research has indicated is important for attention and motor preparation. The diversity of regions showing greater activation among tobacco-exposed children suggests that their brain function is characterized by an inefficient recruitment of regions required for response inhibition.
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影响因子：
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通讯作者：
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