Persistence of the historical lineage I of West Africa against the ongoing spread of the Asian lineage of peste des petits ruminants virus.
Persistence of the historical lineage I of West Africa against the ongoing spread of the Asian lineage of peste des petits ruminants virus.
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DOI：
10.1111/tbed.14066
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发表时间：
2021-11
影响因子：
4.3
通讯作者：
Bataille, Arnaud
中科院分区：
文献类型：
--
作者：
Tounkara, Kadidia;Kwiatek, Olivier;Sidibe, Cheick Abou Kounta;Sery, Amadou;Dakouo, Marthin;Salami, Habib;Lo, Modou Moustapha;Ba, Aminata;Diop, Mariame;Niang, Mamadou;Libeau, Genevieve;Bataille, Arnaud
小反刍兽疫（PPR）是一种小反刍动物的高度传染性疾病。病原体 PPR 病毒 (PPRV) 被分为四个遗传上不同的谱系。 《天堂 IV》起源于亚洲，已展现出在亚洲、中东和非洲传播的独特能力。最近的研究报告称其存在于两个西非国家：尼日利亚和尼日尔。马里和尼日尔之间经常交换动物，这可能导致病毒进入马里和其他西非国家并在那里传播。这里，PPRV 样本是在 2014 年至 2017 年间从马里和与马里边境的塞内加尔的病山羊身上采集的。对部分 PPRV 核蛋白基因进行测序，以确定菌株的遗传谱系。我们的结果显示，2017 年，马里东南部出现了 IV 谱系。这是目前在西非发现的最西边的谱系。令人惊讶的是，我们发现至少到 2014 年，在马里塞古和锡卡索两个地区，被认为已经灭绝的 I 谱系仍然存在。本研究中获得的大多数 PPRV 序列属于谱系 II，该谱系在西非占主导地位。系统发育分析显示，在塞内加尔和马里边境获得的序列之间存在密切关系，支持了病毒在两国之间发生重要传播的假设。了解这些牲畜贸易未完全控制的国家之间动物的流动对于设计有效的控制策略来对抗这种毁灭性疾病非常重要。
Peste des petits ruminants (PPR) is a highly contagious disease of small ruminants. The causal agent, PPR virus (PPRV), is classified into four genetically distinct lineages. Lineage IV, originally from Asia, has shown a unique capacity to spread across Asia, the Middle East and Africa. Recent studies have reported its presence in two West African countries: Nigeria and Niger. Animals are frequently exchanged between Mali and Niger, which could allow the virus to enter and progress in Mali and to other West African countries. Here, PPRV samples were collected from sick goats between 2014 and 2017 in both Mali and in Senegal, on the border with Mali. Partial PPRV nucleoprotein gene was sequenced to identify the genetic lineage of the strains. Our results showed that lineage IV was present in south‐eastern Mali in 2017. This is currently the furthest West the lineage has been detected in West Africa. Surprisingly, we identified the persistence at least until 2014 of the supposedly extinct lineage I in two regions of Mali, Segou and Sikasso. Most PPRV sequences obtained in this study belonged to lineage II, which is dominant in West Africa. Phylogenetic analyses showed a close relationship between sequences obtained at the border between Senegal and Mali, supporting the hypothesis of an important movement of the virus between the two countries. Understanding the movement of animals between these countries, where the livestock trade is not fully controlled, is very important in the design of efficient control strategies to combat this devastating disease.
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DOI：
10.1007/978-3-030-25385-1_3
发表时间：
2019-01-01
期刊：
TRANSBOUNDARY ANIMAL DISEASES IN SAHELIAN AFRICA AND CONNECTED REGIONS
影响因子：
--
作者：
Apolloni, Andrea;Corniaux, Christian;Toure, Ibra
通讯作者：
Toure, Ibra
影响因子：
2.7
作者：
Mantip, Samuel;Quan, Melvyn;van Vuuren, Moritz
通讯作者：
van Vuuren, Moritz
影响因子：
3.2
作者：
Tounkara, Kadidia;Kwiatek, Olivier;Bataille, Arnaud
通讯作者：
Bataille, Arnaud
影响因子：
11.8
作者：
Kwiatek O;Ali YH;Saeed IK;Khalafalla AI;Mohamed OI;Obeida AA;Abdelrahman MB;Osman HM;Taha KM;Abbas Z;El Harrak M;Lhor Y;Diallo A;Lancelot R;Albina E;Libeau G
通讯作者：
Libeau G
影响因子：
4.3
作者：
Souley, Maman Moutari;Ibrahim, Abdoulkarim Issa;Yaou, Bachir
通讯作者：
Yaou, Bachir