The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium.

The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium.
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DOI:
10.1093/nar/gkq879
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发表时间:
2011-01
影响因子:
14.9
通讯作者:
Skarnes WC
Skarnes WC
中科院分区:
生物学2区
文献类型:
--
作者:
Ringwald M;Iyer V;Mason JC;Stone KR;Tadepally HD;Kadin JA;Bult CJ;Eppig JT;Oakley DJ;Briois S;Stupka E;Maselli V;Smedley D;Liu S;Hansen J;Baldock R;Hicks GG;Skarnes WC

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国际基因敲除小鼠联盟(IKMC)旨在利用小鼠胚胎干细胞(ES)中的基因打靶和基因捕获技术组合使小鼠所有的蛋白质编码基因发生突变,并使所产生的资源易于为研究团体获取。IKMC数据库和网络门户(www.knockoutmouse.org)是IKMC数据的中心公共网站,促进了联盟内工作的协调和优先级安排。研究人员可以获取有关特定基因的IKMC基因敲除载体、ES细胞和小鼠的最新信息,并可通过链接进入相应的资源库,从那里可以订购相应的IKMC产品。研究人员还可以使用该网站提名要打靶的基因,或者表明某个基因的打靶应被列为高优先级。IKMC数据库为其他社区数据库提供数据,并与它们有广泛的相互联系。
The International Knockout Mouse Consortium (IKMC) aims to mutate all protein-coding genes in the mouse using a combination of gene targeting and gene trapping in mouse embryonic stem (ES) cells and to make the generated resources readily available to the research community. The IKMC database and web portal (www.knockoutmouse.org) serves as the central public web site for IKMC data and facilitates the coordination and prioritization of work within the consortium. Researchers can access up-to-date information on IKMC knockout vectors, ES cells and mice for specific genes, and follow links to the respective repositories from which corresponding IKMC products can be ordered. Researchers can also use the web site to nominate genes for targeting, or to indicate that targeting of a gene should receive high priority. The IKMC database provides data to, and features extensive interconnections with, other community databases.
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