Preoperative neutrophil-to-lymphocyte ratio is a predictor of recurrence following thermal ablation for recurrent hepatocellular carcinoma: a retrospective analysis.
Preoperative neutrophil-to-lymphocyte ratio is a predictor of recurrence following thermal ablation for recurrent hepatocellular carcinoma: a retrospective analysis.
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术前中性粒细胞与淋巴细胞比率是复发性肝细胞癌热消融后复发的预测因子：回顾性分析
DOI：
10.1371/journal.pone.0110546
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Liang P
中科院分区：
文献类型：
--
作者：
Li X;Han Z;Cheng Z;Yu J;Liu S;Yu X;Liang P
目的本研究的目的是确定术前血液中性粒细胞与淋巴细胞比值（NLR）对复发性肝细胞癌（RHCC）患者热消融后复发的预测价值。材料与方法本回顾性研究纳入了2006年4月至2014年4月接受热消融治疗的506例RHCC患者。评估包括NLR在内的临床病理参数，以确定热消融后复发率的预测因素。采用Cox多元回归分析确定预测RHCC患者复发的参数。采用随时间变化的受试者工作特征（ROC）曲线分析确定NLR的最佳截止值。测定高NLR和低NLR患者的无复发生存率（RFS）。结果多因素Cox比例风险模型分析显示NLR是影响无复发生存的一个预后因素。评估NLR≥2.14 (AUROC = 0.824； P<0.001)， 506例患者中183例（36.2%）NLR大于2.14。随访12 ~ 96个月，低NLR组1年复发率为20.7%，3年复发率为31.6%。复发率明显低于高NLR组（分别为57.9%和82.5%）（P<0.001）。无复发生存分析显示，低NLR组的RFS（67.2%）显著高于高NLR组（13.1%）（P<0.001）。结论术前NLR是RHCC患者热消融后再复发的预测因子。此外，NLR <2.14的患者复发率较低，这可能会改善RHCC患者的临床管理。
Purpose The aim of this study is to determine the predictive value of preoperative blood neutrophil-to-lymphocyte ratio (NLR) for recurrence in recurrent hepatocellular carcinoma (RHCC) patients following thermal ablation. Material and Methods This retrospective study enrolled 506 RHCC patients who underwent thermal ablation from April 2006 to April 2014. The clinicopathological parameters including NLR were evaluated to identify predictors of recurrence rate after thermal ablation. A Cox multiple regression analysis was performed to determine the parameters that predicted recurrence in RHCC patients. The best cutoff value of NLR was determined with time-dependent receiver operating characteristic (ROC) curve analysis. The recurrence-free survival (RFS) rate was determined in patients with high and low NLR. Results The multivariate Cox proportional hazard model analysis showed that NLR was a prognostic factor in recurrence-free survival. NLR ≥2.14 was evaluated (AUROC = 0.824; P<0.001), and 183 of 506 patients (36.2%) had a NLR of more than 2.14. During the follow-up period (12–96 months), the 1-, and 3- year recurrence rates were 20.7% and 31.6% in low NLR group, respectively. These recurrence rates were significantly less than those in the high NLR group (57.9% and 82.5%, respectively) (P<0.001). A recurrence-free survival analyses demonstrated that the RFS in the low NLR group (67.2%) was significantly higher than that in the high NLR group (13.1%) (P<0.001). Conclusion Our results show that preoperative NLR is a predictor for re-recurrence after thermal ablation in RHCC patients. Additionally, patients with NLR <2.14 have a lower recurrence rate, which may improve the clinical management of RHCC patients.
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影响因子：
3.7
作者：
Dan J;Zhang Y;Peng Z;Huang J;Gao H;Xu L;Chen M
通讯作者：
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影响因子：
3.2
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影响因子：
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作者：
Nagai, Shunji;Abouljoud, Marwan S.;Yoshida, Atsushi
通讯作者：
Yoshida, Atsushi