Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution.
Retinal capillary and choriocapillaris assessment using a beam modifier optical coherence tomography angiography module to increase lateral optical resolution.
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DOI：
10.1371/journal.pone.0287783
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
评价一种新的光学相干断层扫描血管造影（OCTA）技术及其对视网膜血管和脉络膜毛细血管（CC）探查的作用。一种名为"扩束器"（BE）的新模块可提高OCTA的横向分辨率，与PLEX® Elite 9000扫频源OCT仪器（ZEISS，都柏林，CA）中的原型软件结合使用。这项前瞻性研究涉及22名健康受试者，有和没有BE成像。对视网膜浅毛细血管丛（SCP）、深毛细血管复合体（DCC）和CC血管造影进行定性分析。还比较了灌注密度（PD）、血管密度（VD）和中心凹无血管区（FAZ）测量值。与标准OCTA图像相比，使用BE采集的单次SCP和DCC视网膜血管造影的定性分析显示血管清晰度显著更好（分别为p = 0.0002和p <0.0001），周边图像质量更高（p = 0.028和p = 0.007）。BE血管造影片的全视网膜单次扫描的平均VD显著高于经典血管造影片（分别为28.16 ± 1.29 mm-1和23.36 ± 0.92 mm-1，p <0.0001）。发现两种方法之间VD、PD和FAZ原始尺寸的重复性相似（组内相关系数：BE为0.671、0.604和0.994，无BE为0.764、0.638和0.990）。发现CC图像质量明显优于BE，与标准扫描相比，所有BE扫描中的血流缺损更明显。OCT光束横向分辨率的增加导致健康受试者的视网膜和脉络膜毛细血管OCTA图像质量更高。这些结果为未来OCTA成像增强提供了重要见解。
To assess a new optical coherence tomography angiography (OCTA) technology and its contribution to retinal vascularization and choriocapillaris (CC) exploration. A new module, named “Beam expander” (BE), which increases the lateral resolution of OCTA, was used in combination with a prototype software in the PLEX® Elite 9000 Swept-Source OCT instrument (ZEISS, Dublin, CA). This prospective study involved 22 healthy subjects imaged with and without BE. Qualitative analysis of superficial capillary plexus (SCP), deep capillary complex (DCC) retinal and CC angiograms were performed. Perfusion density (PD), vessel density (VD), and foveal avascular zone (FAZ) measurements were also compared. Qualitative analysis of single SCP and DCC retinal angiograms acquired with BE showed significantly better vessel sharpness (respectively, p = 0.0002, and p<0.0001), and greater peripheral image quality (p = 0.028 and p = 0.007) compared to standard OCTA images. Mean VD of whole retina single scans was significantly higher for BE angiograms compared to classic angiograms (28.16 ±1.29 mm-1 and 23.36 ±0.92 mm-1, respectively, p<0.0001). Repeatability of VD, PD and FAZ raw size were found to be similar between the two methods (intraclass correlation coefficient: 0.671, 0.604 and 0.994 with BE versus 0.764, 0.638 and 0.990 without BE). CC image quality was found to be significantly superior with BE, and flow deficits were more visible in all BE scans compared to standard scans. An increase in lateral resolution of the OCT beam resulted in higher quality of retinal and choriocapillaris OCTA images in healthy subjects. These results provide significant insights into the future OCTA imaging enhancements.
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影响因子：
4.1
作者：
Fenner, Beau J.;Tan, Gavin S. W.;Cheung, Gemmy C. M.
通讯作者：
Cheung, Gemmy C. M.
影响因子：
3.9
作者：
Tiosano, Liran;Corradetti, Giulia;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.
影响因子：
4.4
作者：
Mo S;Krawitz B;Efstathiadis E;Geyman L;Weitz R;Chui TY;Carroll J;Dubra A;Rosen RB
通讯作者：
Rosen RB
影响因子：
4.2
作者：
Greig, Eugenia Custo;Brigell, Mitchell;Waheed, Nadia K.
通讯作者：
Waheed, Nadia K.
DOI：
10.1097/iae.0000000000002877
发表时间：
2020-11-01
影响因子：
3.3
作者：
Spaide, Richard F.;Ledesma-Gil, Gerardo
通讯作者：
Ledesma-Gil, Gerardo