Repeated cycles of binge-like ethanol (EtOH)-drinking in male C57BL/6J mice augments subsequent voluntary EtOH intake but not other dependence-like phenotypes.
Repeated cycles of binge-like ethanol (EtOH)-drinking in male C57BL/6J mice augments subsequent voluntary EtOH intake but not other dependence-like phenotypes.
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DOI：
10.1111/acer.12145
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Thiele TE
中科院分区：
文献类型：
--
作者：
Cox BR;Olney JJ;Lowery-Gionta EG;Sprow GM;Rinker JA;Navarro M;Kash TL;Thiele TE
最近，已经开发出一些程序来模拟人类酒精滥用疾病的特定方面，包括模拟过度暴饮暴食（即“在黑暗中饮酒”或 DID 程序）和过度依赖类饮酒（即间歇性乙醇蒸气暴露）的程序。类似的神经肽系统调节两种程序引起的过量乙醇饮用，这增加了两种范例实际上模拟相同表型并触发相同中枢神经可塑性的可能性。因此，本项目的目标是使用 DID 程序研究酗酒样乙醇饮酒史对先前通过模拟依赖样饮酒程序描述的表型的影响。雄性 C57BL/6J 小鼠首先经历 0 至 10 次为期 4 天的暴饮暴食发作（两次发作之间休息 3 天）。在最后一次暴饮暴食后 24 小时开始，对小鼠进行焦虑样行为（使用高架十字迷宫 (EPM) 和旷场运动活动测试）、共济失调（使用转棒测试）以及对操作引起的惊厥 (HIC) 的敏感性。一周后，小鼠开始为期 40 天的 2 瓶（水与乙醇）自愿消耗测试，乙醇浓度范围为 10% 至 20%（v/v）。先前的暴饮暴饮史显着增加了随后的自愿乙醇消耗和偏好，这种影响在最初经历 6 或 10 次暴饮暴饮事件的组中最为明显，而在经历 1 次暴饮暴饮事件的小鼠中则完全不存在。相反，酗酒史不会影响焦虑样行为、共济失调或 HIC。 DID 手术引起的过量乙醇最初不会诱导与依赖样状态一致的表型。然而，在反复暴饮暴食后，自愿乙醇消费和偏好的增加可能反映了乙醇依赖的早期阶段，这表明 DID 程序可能是研究向乙醇依赖过渡的理想选择。
Recently, procedures have been developed to model specific facets of human alcohol abuse disorders, including those that model excessive binge-like drinking (i.e., “drinking in the dark”, or DID procedures) and excessive dependence-like drinking (i.e., intermittent ethanol vapor exposure). Similar neuropeptide systems modulate excessive ethanol drinking stemming from both procedures, raising the possibility that both paradigms are actually modeling the same phenotypes and triggering the same central neuroplasticity. Therefore, the goal of the present project was to study the effects of a history of binge-like ethanol drinking, using DID procedures, on phenotypes that have previously been described with procedures to model dependence-like drinking. Male C57BL/6J mice first experienced 0 to 10 4-day binge-like drinking episodes (3 days of rest between episodes). Beginning 24-h after the final binge-like drinking session, mice were tested for anxiety-like behaviors (with elevated plus maze (EPM) and open-field locomotor activity tests), ataxia with the rotarod test, and sensitivity to handling-induced convulsions (HICs). One week later, mice began a 40-day 2-bottle (water versus ethanol) voluntary consumption test with concentration ranging from 10 to 20% (v/v) ethanol. A prior history of binge-like ethanol drinking significantly increased subsequent voluntary ethanol consumption and preference, effects most robust in groups that initially experienced 6 or 10 binge-like drinking episodes and completely absent in mice that experienced 1 binge-like drinking episode. Conversely, a history of binge-like ethanol drinking did not influence anxiety-like behaviors, ataxia, or HICs. Excessive ethanol drinking stemming from DID procedures does not initially induce phenotypes consistent with a dependence-like state. However, the subsequent increases of voluntary ethanol consumption and preference that become more robust following repeated episodes of binge-like ethanol drinking may reflect the early stages of ethanol dependence, suggesting that DID procedures may be ideal for studying the transition to ethanol dependence.
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DOI：
10.1038/npp.2009.209
发表时间：
2010-05
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
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DOI：
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发表时间：
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影响因子：
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影响因子：
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DOI：
10.1111/j.1530-0277.2011.01528.x
发表时间：
2011-10-01
影响因子：
3.2
作者：
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通讯作者：
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