In-vivo detection of white adipose tissue browning: a multimodality imaging approach.
In-vivo detection of white adipose tissue browning: a multimodality imaging approach.
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DOI：
10.1038/s41598-023-42537-9
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发表时间：
2023-09-19
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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人类棕色脂肪的检测和分化面临几个挑战，因为这种组织稀疏，经常与白色脂肪组织混合。米色脂肪的非侵入性检测是一个更大的挑战，因为这种组织在结构和功能上更像白色脂肪而不是棕色脂肪。在这里，我们使用18f -氟脱氧葡萄糖正电子发射断层扫描、计算机断层扫描、氙增强计算机断层扫描和动态对比增强超声，以非侵入性地检测β3-肾上腺素受体激动剂CL-316243慢性刺激小鼠腹股沟白色脂肪褐变过程相关的功能和结构变化。这些研究显示，基线组织放射密度和氙增强放射密度的增加非常不均匀，表明脂肪细胞水和蛋白质含量以及组织灌注都增加，主要是在CL-316243治疗前显示去甲肾上腺素刺激灌注增强的区域。在CL-316243处理后，小鼠的18f -氟脱氧葡萄糖摄取或去甲肾上腺素刺激的组织灌注未见统计学显著增加。组织含水量和灌注的增加，以及组织葡萄糖摄取和去甲肾上腺素刺激的灌注的可忽略不计的增加值得更多的关注，特别是考虑到该组织在全身代谢中可能发挥的潜在代谢作用。
Detection and differentiation of brown fat in humans poses several challenges, as this tissue is sparse and often mixed with white adipose tissue. Non-invasive detection of beige fat represents an even greater challenge as this tissue is structurally and functionally more like white fat than brown fat. Here we used positron emission tomography with 18F-fluorodeoxyglucose, computed tomography, xenon-enhanced computed tomography, and dynamic contrast-enhanced ultrasound, to non-invasively detect functional and structural changes associated with the browning process of inguinal white fat, induced in mice by chronic stimulation with the β3-adrenergic receptor agonist CL-316243. These studies reveal a very heterogeneous increase in baseline tissue radiodensity and xenon-enhanced radiodensity, indicative of both an increase in adipocytes water and protein content as well as tissue perfusion, mostly in regions that showed enhanced norepinephrine-stimulated perfusion before CL-316243 treatment. No statistically significant increase in 18F-fluorodeoxyglucose uptake or norepinephrine-stimulated tissue perfusion were observed in the mice after the CL-316243 treatment. The increase in tissue-water content and perfusion, along with the negligible increase in the tissue glucose uptake and norepinephrine-stimulated perfusion deserve more attention, especially considering the potential metabolic role that this tissue may play in whole body metabolism.
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DOI：
10.1073/pnas.1714431115
发表时间：
2018-01-02
影响因子：
11.1
作者：
Branca, Rosa T.;McCallister, Andrew;Burant, Alex
通讯作者：
Burant, Alex
影响因子：
5.8
作者：
Carmen Soler-Vazquez, M.;Mera, Paula;Herrero, Laura
通讯作者：
Herrero, Laura
影响因子：
6.5
作者：
Chan, Xin Hui Derryn;Balasundaram, Ghayathri;Sugii, Shigeki
通讯作者：
Sugii, Shigeki
影响因子：
20.8
作者：
de Jong, Jasper M. A.;Sun, Wenfei;Petrovic, Natasa
通讯作者：
Petrovic, Natasa
影响因子：
4.7
作者：
通讯作者：
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