Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery.
Ultrasound-mediated disruption of the blood tumor barrier for improved therapeutic delivery.
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DOI：
10.1016/j.neo.2021.04.005
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Lockman PR
中科院分区：
文献类型：
--
作者：
Arsiwala TA;Sprowls SA;Blethen KE;Adkins CE;Saralkar PA;Fladeland RA;Pentz W;Gabriele A;Kielkowski B;Mehta RI;Wang P;Carpenter JS;Ranjan M;Najib U;Rezai AR;Lockman PR
血脑屏障（blood-brain barrier，BBB）是限制药物进入脑内的主要解剖和生理屏障。中枢神经系统肿瘤可以通过改变肿瘤微环境来损害BBB，导致形成渗漏屏障，称为血液肿瘤屏障（BTB）。尽管完整性发生了变化，但BTB仍然有效地阻止了化疗药物进入脑肿瘤。聚焦超声是一种独特的非侵入性技术，可以短暂破坏BBB并增加药物在大脑目标区域内的积累。在此，我们总结了目前对不同类型的靶向超声介导的BBB/BTB破坏技术的理解。我们还讨论了肿瘤微环境对血脑屏障开放的影响，以及破坏后免疫反应的作用。最后，我们强调了BBB/BTB开放参数的评估之间的差距。对BBB/BTB的物理开放和破坏后的生物学效应的更深入了解可能会增强脑肿瘤患者的治疗策略。
The blood-brain barrier (BBB) is a major anatomical and physiological barrier limiting the passage of drugs into brain. Central nervous system tumors can impair the BBB by changing the tumor microenvironment leading to the formation of a leaky barrier, known as the blood-tumor barrier (BTB). Despite the change in integrity, the BTB remains effective in preventing delivery of chemotherapy into brain tumors. Focused ultrasound is a unique noninvasive technique that can transiently disrupt the BBB and increase accumulation of drugs within targeted areas of the brain. Herein, we summarize the current understanding of different types of targeted ultrasound mediated BBB/BTB disruption techniques. We also discuss influence of the tumor microenvironment on BBB opening, as well as the role of immunological response following disruption. Lastly, we highlight the gaps between evaluation of the parameters governing opening of the BBB/BTB. A deeper understanding of physical opening of the BBB/BTB and the biological effects following disruption can potentially enhance treatment strategies for patients with brain tumors.
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影响因子：
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DOI：
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DOI：
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发表时间：
2016-06
期刊：
Drug discovery today. Technologies
影响因子：
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作者：
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通讯作者：
Lammers, Twan