Rickettsia-Host-Tick Interactions: Knowledge Advances and Gaps.
Rickettsia-Host-Tick Interactions: Knowledge Advances and Gaps.
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DOI：
10.1128/iai.00621-21
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发表时间：
2022-09-15
影响因子：
3.1
通讯作者：
中科院分区：
文献类型：
--
作者：
蜱是吸血性体外寄生虫，能够传播多种人类病原体。环境变化支持蜱虫扩展到新的地理区域，这些区域已成为蜱传疾病（TBD）的中心。立克次体的斑点热群（SFG）经常感染蜱虫，并在蜱虫在吸血期间支持宿主传播的地方性地区引起蜱传播立克次体病。蜱虫也是SFG立克次体的宿主。在SFG立克次体成员中，R.立克次氏体引起落基山斑疹热（RMSF），这是美国最致命的TBD。世纪以来，在美国报告了与几种蜱有关的RMSF病例。然而，R.来自蜱的立克次氏体已经减少，最近的血清学和流行病学研究表明，SFG立克次体的新物种是美国RSF样立克次体病病例数量增加的原因。最近对立克次体基因组的分析以及立克次体遗传和分子研究的进展为立克次体生物学提供了新的见解，并确定了立克次体生命周期中保守和独特的推定毒力基因。因此，了解立克次体-宿主-蜱相互作用介导成功的疾病传播和SFG立克次体的发病机制仍然是一个活跃的研究领域。本文综述了近年来在了解SFG立克次体物种如何引诱和操纵蜱和哺乳动物宿主引起立克次体病方面的进展，特别强调新描述或新出现的SFG立克次体物种。
Ticks are hematophagous ectoparasites capable of transmitting multiple human pathogens. Environmental changes have supported the expansion of ticks into new geographical areas that have become the epicenters of tick-borne diseases (TBDs). The spotted fever group (SFG) of Rickettsia frequently infects ticks and causes tick-transmitted rickettsioses in areas of endemicity where ixodid ticks support host transmission during blood feeding. Ticks also serve as a reservoir for SFG Rickettsia. Among the members of SFG Rickettsia, R. rickettsii causes Rocky Mountain spotted fever (RMSF), the most lethal TBD in the United States. Cases of RMSF have been reported for over a century in association with several species of ticks in the United States. However, the isolation of R. rickettsii from ticks has decreased, and recent serological and epidemiological studies suggest that novel species of SFG Rickettsia are responsible for the increased number of cases of RMSF-like rickettsioses in the United States. Recent analyses of rickettsial genomes and advances in genetic and molecular studies of Rickettsia provided insights into the biology of Rickettsia with the identification of conserved and unique putative virulence genes involved in the rickettsial life cycle. Thus, understanding Rickettsia-host-tick interactions mediating successful disease transmission and pathogenesis for SFG rickettsiae remains an active area of research. This review summarizes recent advances in understanding how SFG Rickettsia species coopt and manipulate ticks and mammalian hosts to cause rickettsioses, with a particular emphasis on newly described or emerging SFG Rickettsia species.
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影响因子：
3.7
作者：
Matsutani M;Ogawa M;Takaoka N;Hanaoka N;Toh H;Yamashita A;Oshima K;Hirakawa H;Kuhara S;Suzuki H;Hattori M;Kishimoto T;Ando S;Azuma Y;Shirai M
通讯作者：
Shirai M
影响因子：
3.7
作者：
Allerdice MEJ;Paddock CD;Hecht JA;Goddard J;Karpathy SE
通讯作者：
Karpathy SE
影响因子：
11.8
作者：
Ando S;Kurosawa M;Sakata A;Fujita H;Sakai K;Sekine M;Katsumi M;Saitou W;Yano Y;Takada N;Takano A;Kawabata H;Hanaoka N;Watanabe H;Kurane I;Kishimoto T
通讯作者：
Kishimoto T
影响因子：
3.3
作者：
Alvarez-Lopez, Diego, I;Ochoa-Mora, Estefania;Armstrong, Paige A.
通讯作者：
Armstrong, Paige A.
影响因子：
3.2
作者：
Clark, Tina R.;Lackey, Amanda M.;Hackstadt, Ted
通讯作者：
Hackstadt, Ted