Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract.
Modelling dynamic change of malaria transmission in holoendemic setting (Dielmo, Senegal) using longitudinal measures of antibody prevalence to Plasmodium falciparum crude schizonts extract.
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DOI：
10.1186/s12936-017-2052-0
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发表时间：
2017-10-11
期刊：
影响因子：
3
通讯作者：
Toure Balde A
中科院分区：
文献类型：
--
作者：
Niass O;Saint-Pierre P;Niang M;Diop F;Diouf B;Faye MM;Sarr FD;Faye J;Diagne N;Sokhna C;Trape JF;Perraut R;Tall A;Diongue AK;Toure Balde A
以前曾使用基于对单一抗原的抗体反应的流行程度的可逆催化模型来评估血清转换率，以评估当地恶性疟原虫的传播。血清转换率和昆虫学接种率(EIR)之间有很高的相关性。然而，在这个模型中，没有评估疟疾控制干预措施和临床事件对血清学测量的影响。这项研究监测对恶性疟原虫粗提物的抗体反应用于评估疟疾传播，比较从纵向数据估计的血清转换率和从横断面调查得出的血清转换率，并在疟疾传播下降的地区调查疟疾控制干预措施对这些措施的影响。此外，通过与备选模型的比较，评价了该模型的有效性。2000年、2002年、2008年、2010年和2012年，在塞内加尔疟疾流行的农村地区Dielmo，在雨季结束时进行了五次横断面调查。用酶联免疫吸附试验(EL ISA)检测了适应培养的恶性疟原虫地方株(PF 07/03)裂殖体粗提物的抗体。横断面调查和纵向数据(所有调查的综合数据)都使用了年龄特定的血清阳性率模型。本研究使用了350名受试者数年随访所得的1504份血浆样本。基于恶性疟原虫裂殖体粗提物的血清转换率在每一项横断面调查中被估计，并被发现与EIR密切相关。从横断面调查和纵向调查中观察到的SCR之间具有很高的变异性。在纵向研究中，替代催化可逆模型比催化模型更好地调整了血清学数据。临床疟疾发作和疟疾控制干预措施被发现对血清转化率有显著影响。研究结果表明，粗提物是一种很好的血清学工具，可用于评估疟疾传播正在下降的地区的疟疾暴露水平。然而，必须考虑其他参数，如临床疟疾和疟疾控制干预措施，以确定血清学测量，以便在传播评估中更准确。本文的在线版本(doi：10.1186/s12936-0172052-0)包含补充材料，授权用户可以使用。
Evaluation of local Plasmodium falciparum malaria transmission has been investigated previously using the reversible catalytic model based on prevalence of antibody responses to single antigen to estimate seroconversion rates. High correlations were observed between seroconversion rates and entomological inoculation rates (EIR). However, in this model, the effects of malaria control interventions and clinical episodes on serological measurements were not assessed. This study monitors the use of antibody responses to P. falciparum crude extracts for assessing malaria transmission, compares seroconversion rates estimated from longitudinal data to those derived from cross-sectional surveys and investigates the effects of malaria control interventions on these measures in an area of declining malaria transmission. In addition, the validity of this model was evaluated by comparison with the alternative model. Five cross-sectional surveys were carried out at the end of the wet season in Dielmo, a malaria-endemic Senegalese rural area in 2000, 2002, 2008, 2010 and 2012. Antibodies against schizonts crude extract of a local P. falciparum strain adapted to culture (Pf 07/03) were measured by ELISA. Age-specific seroprevalence model was used both for cross-sectional surveys and longitudinal data (combined data of all surveys). A total of 1504 plasma samples obtained through several years follow-up of 350 subjects was used in this study. Seroconversion rates based on P. falciparum schizonts crude extract were estimated for each cross-sectional survey and were found strongly correlated with EIR. High variability between SCRs from cross-sectional and longitudinal surveys was observed. In longitudinal studies, the alternative catalytic reversible model adjusted better with serological data than the catalytic model. Clinical malaria attacks and malaria control interventions were found to have significant effect on seroconversion. The results of the study suggested that crude extract was a good serological tool that could be used to assess the level of malaria exposure in areas where malaria transmission is declining. However, additional parameters such as clinical malaria and malaria control interventions must be taken into account for determining serological measurements for more accuracy in transmission assessment. The online version of this article (doi:10.1186/s12936-017-2052-0) contains supplementary material, which is available to authorized users.
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影响因子：
3
作者：
Kelly-Hope LA;McKenzie FE
通讯作者：
McKenzie FE
影响因子：
3
作者：
Diop, Fode;Richard, Vincent;Balde, Aissatou Toure
通讯作者：
Balde, Aissatou Toure
影响因子：
3
作者：
Kusi, Kwadwo A.;Bosomprah, Samuel;Koram, Kwadwo A.
通讯作者：
Koram, Kwadwo A.
影响因子：
3.7
作者：
Arnold, Benjamin F.;Priest, Jeffrey W.;Lammie, Patrick J.
通讯作者：
Lammie, Patrick J.
DOI：
10.1073/pnas.0408725102
发表时间：
2005-04-05
影响因子：
11.1
作者：
Drakeley, CJ;Corran, PH;Riley, EM
通讯作者：
Riley, EM