Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans?
复制标题
DOI：
10.1007/s00198-013-2464-9
复制
发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Celi FS
中科院分区：
文献类型：
--
作者：
Lee P;Linderman J;Smith S;Brychta RJ;Perron R;Idelson C;Werner CD;Chen KY;Celi FS
在动物中，高成纤维细胞生长因子 21 (FGF21) 状态可改善胰岛素抵抗，但会导致骨质流失。 FGF21 是否与人类骨矿物质密度 (BMD) 相关尚不清楚。与动物研究结果的预测相反，我们发现女性较高的 FGF21 水平与较高的 BMD 相关，与年龄和身体成分无关。最近的实验室研究表明 FGF21 参与骨和能量稳态的相互调节。全身施用 FGF21 可以保护动物免受肥胖和糖尿病的影响，但会导致严重的骨质流失，从而扼杀了人们对 FGF21 作为潜在抗肥胖治疗药物的热情。迄今为止，尚无关于 FGF21 是否与人类 BMD 相关的信息。因此，我们研究了健康成人血浆 FGF21 水平与 BMD 之间的关系。通过酶联免疫吸附测定法测量空腹血浆 FGF21 水平，通过双能 X 射线吸收法测量身体成分。在 40 名健康志愿者（年龄 32±10 岁，16 名女性）中，男性的去脂体重 (p<0.01) 和总 BMD (p<0.05) 显着高于女性，而体脂百分比则低于女性 (p<0.01)。男女之间血浆 FGF21 中位水平没有差异。虽然男性中的 FGF21 浓度与身体成分之间没有关联，但女性中的 FGF21 水平与脂肪量呈正相关 (p<0.01)。在男性中，未观察到 FGF21 与 BMD 之间存在显着相关性。然而，在女性中，FGF21 与总 BMD（R2=0.69，p=0.003）和脊柱 BMD（R2=0.76，p=0.001）呈正相关；调整年龄、种族和身体成分后，相关性仍然显着。结论 这项研究首次揭示了健康女性血浆 FGF21 水平与 BMD 之间的强正相关关系，表明动物骨质流失与高 FGF21 状态之间的关联可能不会直接转化为生理状态下的人类。我们假设 FGF21 可能通过骨-脂肪界面的旁分泌机制增加骨量，特别是女性的骨量。
In animals, high fibroblast growth factor 21 (FGF21) states improve insulin resistance but induce bone loss. Whether FGF21 relates to bone mineral density (BMD) is unknown in humans. Contrary to prediction from animal findings, we found higher FGF21 levels associating with greater BMD in women, independent of age and body composition. Recent laboratory studies suggest that FGF21 is involved in reciprocal regulation of bone and energy homeostasis. Systemic administration of FGF21 protects animals from obesity and diabetes but causes severe bone loss, smothering the enthusiasm over FGF21 as a potential antiobesity therapeutic. To date, there is no information on whether FGF21 relates to BMD in humans. We thus studied the relationship between plasma FGF21 levels and BMD in healthy adults. Fasting plasma FGF21 levels were measured by enzyme-linked immunosorbent assay and body composition by dual-energy X-ray absorptiometry. Among 40 healthy volunteers (age 32±10 year, 16 women), men had significantly higher lean body mass (p<0.01) and total BMD (p<0.05), and lower percent body fat than women (p<0.01). Median plasma FGF21 levels were not different between the sexes. While there was no association between FGF21 concentrations and body composition in men, FGF21 levels correlated positively with fat mass (p<0.01) in women. In men, no significant correlation between FGF21 with BMD was observed. However, in women, FGF21 correlated positively with total BMD (R2=0.69, p=0.003) and spine BMD (R2=0.76, p=0.001); the correlation remained significant after adjusting for age, ethnicity, and body composition. Conclusions This study reveals for the first time a strong positive association between plasma FGF21 levels and BMD in healthy women, suggesting the association between bone loss and high FGF21 states in animals may not be directly translated to humans in physiologic states. We hypothesize that FGF21 may increase bone mass particularly in women through paracrine mechanisms in the bone–adipose interface.
登录
查看更多内容
冷激活的棕色脂肪组织是女性较高骨矿物质密度的独立预测指标。
DOI：
10.1007/s00198-012-2110-y
发表时间：
2013-04
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Lee P;Brychta RJ;Collins MT;Linderman J;Smith S;Herscovitch P;Millo C;Chen KY;Celi FS
通讯作者：
Celi FS
影响因子：
4.1
作者：
Krings, A.;Rahman, S.;Huang, S.;Lu, Y.;Czernik, P. J.;Lecka-Czernik, B.
通讯作者：
Lecka-Czernik, B.
DOI：
10.1016/j.bbrc.2013.02.019
发表时间：
2013-03-22
影响因子：
3.1
作者：
Ishida, Kazunari;Haudenschild, Dominik R.
通讯作者：
Haudenschild, Dominik R.
DOI：
10.4158/ep12141.ra
发表时间：
2012-09
期刊：
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
影响因子：
--
作者：
Guntur AR;Rosen CJ
通讯作者：
Rosen CJ
影响因子：
29
作者：
Nishio, Miwako;Yoneshiro, Takeshi;Saeki, Kumiko
通讯作者：
Saeki, Kumiko