Pharmacokinetic study of the major chemical constituents in Xanthoceras sorbifolia wood after oral administration of methanol extract, wood powder, and single constituents
Pharmacokinetic study of the major chemical constituents in Xanthoceras sorbifolia wood after oral administration of methanol extract, wood powder, and single constituents
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文冠果甲醇提取物、木粉及单一成分口服后主要化学成分的药代动力学研究
DOI：
10.1080/10826076.2018.1426600
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发表时间：
2018-02
影响因子：
1.3
通讯作者：
Chao-Mei Ma
中科院分区：
文献类型：
--
作者：
Dan-Dan Wu;Yan Ma;Yu Zhang;Jukov Azzaya;Chao-Mei Ma
摘要文冠果木粉和提取物在蒙医中用于治疗风湿、痛风等疾病。需要关于不同形式的草药之间的药代动力学差异的信息。采用超液相色谱-三重四极杆质谱法同时测定了大鼠血浆中的8种文冠果成分。体外实验研究了消化液对药物动力学的影响。表没食子儿茶素和二氢杨梅素在灌胃松材线虫提取物的大鼠中的AUC值高于纯化合物。苍耳木粉灌胃大鼠的表儿茶素AUC值高于甲醇提取物灌胃的大鼠。木粉中不可提取的表儿茶素聚合物可被胃液降解为表儿茶素，从而提高血液中的表儿茶素水平。图形摘要
ABSTRACT The wood powder and extract of Xanthoceras sorbifolia are used to treat rheumatism, gout, and other diseases in Mongolian medicine. Information on the pharmacokinetic differences between various forms of the herb drug is needed. Eight Xanthoceras constituents were examined simultaneously in rat plasma by ultra liquid chromatography-triple quadrupole mass spectrometry. In vitro experiments were performed to determine the influence of digestive juices on the pharmacokinetic profiles. Epicatechin and dihydromyricetin had higher AUC values in rats that were gavaged with X. sorbifolia extract versus the pure compounds. The AUC value of epicatechin in rats that were gavaged with X. sorbifolia wood powder was higher than that with the methanol extract. The nonextractable epicatechin polymer in the wood powder could be degraded to epicatechin by gastric juice, consequently elevating the epicatechin levels in blood. GRAPHICAL ABSTRACT
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DOI：
10.3746/jfn.2005.10.4.326
发表时间：
2005-12
期刊：
Journal of Food Science and Nutrition
影响因子：
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作者：
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Advanced Materials Research
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DOI：
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发表时间：
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影响因子：
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