3D printed optical phantoms and deep tissue imaging for in vivo applications including oral surgery

3D printed optical phantoms and deep tissue imaging for in vivo applications including oral surgery
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3D 打印光学体模和深层组织成像,用于口腔手术等体内应用

DOI:
10.1117/12.2253763
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发表时间:
2017
期刊:
Biomedical optics
影响因子:
--
通讯作者:
K. Webb
K. Webb
中科院分区:
--
文献类型:
--
作者:
B. Bentz;Alfonso Costas;V. Gaind;J. García;K. Webb

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在开发用于生物医学应用的光学成像方面的进展需要用于测试、评估和校准的可定制且通常是复杂的对象,称为“模体”。这项工作表明,3D打印是制造此类物品的理想方法,允许将复杂的不均匀放置在复杂或解剖逼真的几何图形的准确位置,这一过程使用模具是困难或不可能的。我们展示了我们为开发深层组织荧光成像方法而制造的打印小鼠模型,并测量了它们的光学和机械性能。此外,我们提出了一个打印的人类口腔体模,我们使用它来开发一种动脉定位方法,以辅助口腔手术。
Progress in developing optical imaging for biomedical applications requires customizable and often complex objects known as "phantoms" for testing, evaluation, and calibration. This work demonstrates that 3D printing is an ideal method for fabricating such objects, allowing intricate inhomogeneities to be placed at exact locations in complex or anatomically realistic geometries, a process that is difficult or impossible using molds. We show printed mouse phantoms we have fabricated for developing deep tissue fluorescence imaging methods, and measurements of both their optical and mechanical properties. Additionally, we present a printed phantom of the human mouth that we use to develop an artery localization method to assist in oral surgery.
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