Visualizing cancer extravasation: from mechanistic studies to drug development.
Visualizing cancer extravasation: from mechanistic studies to drug development.
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DOI：
10.1007/s10555-020-09942-2
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Cheng K
中科院分区：
文献类型：
--
作者：
Cheng X;Cheng K
转移是一个多步骤的过程，占大多数癌症相关死亡的原因。在转移传播结束时，循环肿瘤细胞（ctc）需要在转移部位外渗血管以形成新的定植。虽然癌细胞外渗是癌症转移的关键步骤，但由于缺乏对这一过程的调控分子机制的透彻理解，目前的抗转移策略尚未成功靶向这一过程。本文综述了肿瘤外渗可视化技术的最新进展，包括体外和体内肿瘤外渗模型的发展，揭示了潜在的机制。具体来说，使用这些技术可以成功地探索多种癌症外渗阶段，如内皮粘附和跨内皮迁移。此外，还阐述了不同的细胞粘附分子、趋化因子、生长因子以及机械因素在这些阶段中的作用。对肿瘤外渗机制的深入了解为我们进一步发现抗外渗药物和治疗方法以及改善癌症患者的预后提供了新的机会。
Metastasis is a multistep process that accounts for the majority of cancer-related death. By the end of metastasize dissemination, circulating tumor cells (CTCs) need to extravasate the blood vessels at metastatic sites to form new colonization. Although cancer cell extravasation is a crucial step in cancer metastasis, it has not been successfully targeted by current anti-metastasis strategies due to the lack of a thorough understanding of the molecular mechanisms that regulate this process. This review focuses on recent progress in cancer extravasation visualization techniques, including the development of both in vitro and in vivo cancer extravasation models, that shed light on the underlying mechanisms. Specifically, multiple cancer extravasation stages, such as the adhesion to the endothelium and transendothelial migration, are successfully probed using these technologies. Moreover, the roles of different cell adhesive molecules, chemokines, growth factors, as well as the mechanical factors in these stages are well illustrated. Deeper understandings of cancer extravasation mechanisms offer us new opportunities to escalate the discovery of anti-extravasation drugs and therapies and improve the prognosis of cancer patients.
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影响因子：
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影响因子：
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