Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.
Response inhibition and fronto-striatal-thalamic circuit dysfunction in cocaine addiction.
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DOI：
10.1016/j.drugalcdep.2018.07.037
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发表时间：
2018-11-01
影响因子：
4.2
通讯作者：
Li CR
中科院分区：
文献类型：
--
作者：
Wang W;Worhunsky PD;Zhang S;Le TM;Potenza MN;Li CR
许多研究已经调查了可卡因成瘾对认知控制的影响。在这里，我们通过使用空间独立分量分析(ICA)来扩展这一文献，以描述与可卡因成瘾的反应抑制障碍有关的回路功能障碍。55名可卡因依赖者(CD)和55名年龄和性别匹配的非吸毒健康对照组(HC)参与了这项研究。对40个独立成分(IC)的任务相关性进行多元回归分析，将血流动力学活动的时间历程与Go成功(GS)、Stop Success(SS)和Stop Error(S)进行模拟。这一过程产生了表示每个IC在时间上与每个任务事件相关联或被每个任务事件‘参与’的程度的Beta-Weight。在行为上，CD参与者的停止信号反应时间(SSRT)比HC参与者要长(p<；0.01)。ICA确定了两个网络，显示了CD和HC在与SS相关的参与方面的差异(p<；0.05，FDR校正)。额纹状体丘脑网络的活动与SSRTS呈负相关，但在CD个体中无相关性，提示该网络在CD个体反应抑制缺陷的调节中起着特殊的作用。相反，额顶颞叶网络的参与与SSRT无关，同样在SS和SE试验中参与较少，可能反映了可卡因成瘾的注意力障碍。这项研究强调了ICA在识别与SST表现相关的神经回路参与方面的效用，并表明特定的网络可能是纠正可卡因成瘾中执行控制障碍的重要靶点。
Many studies have investigated how cognitive control may be compromised in cocaine addiction. Here, we extend this literature by employing spatial Independent Component Analysis (ICA) to describe circuit dysfunction in relation to impairment in response inhibition in cocaine addiction. Fifty-five cocaine-dependent (CD) and 55 age- and sex-matched non-drug-using healthy control individuals (HC) participated in the study. Task-relatedness of 40 independent components (ICs) was assessed using multiple regression analyses of component time courses with the modeled time courses of hemodynamic activity convolved with go success (GS), stop success (SS) and stop error (S ). This procedure produced beta-weights that represented the degree to which each IC was temporally associated with, or ‘engaged’, by each task event. Behaviorally, CD participants showed prolonged stop signal reaction times (SSRTs) as compared to HC participants (p<0.01). ICA identified two networks that showed differences in engagement related to SS between CD and HC (p<0.05, FDR-corrected). The activity of the fronto-striatal-thalamic network was negatively correlated with SSRTs in HC but not in CD, suggesting a specific role of this network in mediating deficits of response inhibition in CD individuals. In contrast, the engagement of the fronto-parietal-temporal network did not relate to SSRTs, was similarly less engaged for both SS and SE trials, and may reflect attentional dysfunction in cocaine addiction. This study highlights the utility of ICA in identifying neural circuitry engagement related to SST performance and suggests that specific networks may represent important targets in remedying executive-control impairment in cocaine addiction.
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影响因子：
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作者：
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