Anti-Inflammatory Benefits of Food Ingredients in Periodontal Diseases.
Anti-Inflammatory Benefits of Food Ingredients in Periodontal Diseases.
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DOI：
10.3390/pathogens12040520
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发表时间：
2023-03-27
期刊：
影响因子：
--
通讯作者：
Araujo de Godoi M
中科院分区：
文献类型：
--
作者：
Papathanasiou E;Alreshaid R;Araujo de Godoi M
牙周炎是一种多方面的炎症性疾病，影响牙龈和支撑牙齿的结构，最终可能增加牙齿的流动性和牙齿脱落的风险。炎症是生物（饮食）和宿主调节剂/药物的牙周炎的可行治疗靶点。牙周炎的传统治疗方法，包括非手术或手术牙周治疗以及偶尔的预防性抗菌治疗，都只有轻微的效果。营养不良，或至少不良的饮食习惯，可以在牙周病患者中非常普遍。由于几种食物营养素可以帮助牙周愈合和再生，因此迫切需要评估天然膳食来源和补充成分，以平衡炎症过程并改善患者的牙周状况。在这里，我们回顾了目前的知识状态（检索期：2010年至2022年; PubMed和Web of Science）在牙周病患者的临床研究中，食品成分和补充剂的抗炎作用。包括水果和蔬菜，omega-3多不饱和脂肪酸以及维生素和植物衍生化合物补充剂的饮食似乎可以对抗牙龈炎症，并对牙周病患者有很好的治疗效果。尽管有积极的迹象表明，几种营养素可以作为牙周治疗的辅助手段，但需要更多的研究，更大的样本量和更长的随访期，以阐明其治疗效果和最有效的剂量和管理。
Periodontitis is a multi-faceted inflammatory disease that impacts the gingiva and the structures that support our teeth, and may eventually increase tooth mobility and the risk of tooth loss. Inflammation is a viable therapeutic target of periodontitis for both biologic (dietary) and host modulatory agents/drugs. Conventional therapeutic approaches for periodontitis, including nonsurgical or surgical periodontal therapy as well as occasional adjunctive antimicrobial therapy, have been only marginally effective. Malnutrition, or at least poor dietary habits, can be highly prevalent among patients with periodontal diseases. As several food nutrients can aid in periodontal healing and regeneration, there is a critical need to evaluate natural dietary sources and supplement ingredients that can counterbalance the inflammatory processes and improve the periodontal status of our patients. Here, we reviewed the current state of knowledge (search period: 2010 to 2022; PubMed and Web of Science) on the anti-inflammatory actions of food ingredients and supplements in clinical studies of patients with periodontal diseases. A diet that includes fruits and vegetables, omega-3 polyunsaturated fatty acids, and supplements of vitamins and plant-derived compounds seems to counteract gingival inflammation and has a promising therapeutic impact in patients with periodontal diseases. Despite the positive indications that several nutrients can be used as an adjunct to periodontal therapy, additional studies with bigger sample sizes and longer follow-up periods are needed to elucidate their therapeutic benefits and the most effective doses and administration.
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影响因子：
4.2
作者：
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