Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development.
Mandibular arch muscle identity is regulated by a conserved molecular process during vertebrate development.
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下颌弓肌肉的特性受到脊椎动物发育过程中保守的分子过程的调节。
DOI：
10.1002/jez.b.21215
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Knight RD
中科院分区：
文献类型：
--
作者：
Knight RD
脊椎动物头部肌肉表现出高度保守的神经支配和骨骼连接模式，但目前还不清楚它们发育的分子基础是否同样保守。使用高度保守的表达Engrailed 2（En 2）作为身份的标记，在背下颌骨肌肉的斑马鱼，我们已经调查了分子信号和组织图案化这些肌肉所需的。我们发现，肌肉En 2的表达是不依赖于信号从相邻的神经管，咽内胚层或轴向中胚层和头部肌肉的早期身份不需要骨形态发生途径，Notch或刺猬（Hh）信号。然而，缩背肌En 2的表达是完全失去后，成纤维细胞生长因子（Fgf）信号转导的损失，我们表明，这是真实的整个头部肌肉发育。这些结果表明，头部肌肉的身份是依赖于FGF信号。在鸡进行的实验数据表明，类似的调节En 2基因的成纤维细胞生长因子信号揭示了一个保守的机制，指定头部肌肉的身份。我们目前的证据表明，另一个关键基因在小鼠头部肌肉的发展，Tbx 1，也是至关重要的下颌弓肌肉的身份规格，这是独立的FGF信号。这些数据意味着，尽管这些肌肉在不同的谱系中具有不同的功能，但鱼、鸡和小鼠的下颌背弓肌肉的特性是由高度保守的分子过程指定的。Zool.（Mol. Dev. Evol.）310 B：355-369，2008.© 2008 Wiley利斯公司
Vertebrate head muscles exhibit a highly conserved pattern of innervation and skeletal connectivity and yet it is unclear whether the molecular basis of their development is likewise conserved. Using the highly conserved expression of Engrailed 2 (En2) as a marker of identity in the dorsal mandibular muscles of zebrafish, we have investigated the molecular signals and tissues required for patterning these muscles. We show that muscle En2 expression is not dependent on signals from the adjacent neural tube, pharyngeal endoderm or axial mesoderm and that early identity of head muscles does not require bone morphogenetic pathway, Notch or Hedgehog (Hh) signalling. However, constrictor dorsalis En2 expression is completely lost after a loss of fibroblast growth factor (Fgf) signalling and we show that is true throughout head muscle development. These results suggest that head muscle identity is dependent on Fgf signalling. Data from experiments performed in chick suggest a similar regulation of En2 genes by Fgf signalling revealing a conserved mechanism for specifying head muscle identity. We present evidence that another key gene important in the development of mouse head muscles,Tbx1, is also critical for specification of mandibular arch muscle identity and that this is independent of Fgf signalling. These data imply that dorsal mandibular arch muscle identity in fish, chick and mouse is specified by a highly conserved molecular process despite differing functions of these muscles in different lineages.J. Exp. Zool. (Mol. Dev. Evol.) 310B:355–369, 2008. © 2008 Wiley‐Liss, Inc.
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DOI：
--
发表时间：
1993
期刊：
Development, Growth and Differentiation
影响因子：
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影响因子：
2.4
作者：
Sabo,MichelleC;Nath,Kimberly;Elinson,RichardP
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