Cross-sectional exploration of brain functional connectivity in the triadic development model of adolescents
Cross-sectional exploration of brain functional connectivity in the triadic development model of adolescents
复制标题
青少年三元发展模型中大脑功能连接的横断面探索
DOI：
10.1007/s11682-020-00379-3
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发表时间：
2020-09
影响因子：
3.2
通讯作者：
Zhihao Li
中科院分区：
文献类型：
--
作者：
Wenjing Xu;Fuxian Ying;Yuejia Luo;Xiao-Yong Zhang;Zhihao Li
青春期是一个过渡阶段，风险增加，情绪失调。这些脆弱性是由奖励寻求（REW），情绪回避（EMO）和认知调节（COG）的三元功能脑网络中的发展动态引起的。然而，这些三元动力学，虽然概念上建立，尚未直接调查。本研究利用222名青少年（89F133M）静息态fMRI数据库，通过联合考虑腹侧纹状体、杏仁核和背外侧前额叶皮质的双侧种子分别探测REW、EMO和COG网络，探讨了功能连接（FC）的横截面发育概况。分别考虑阳性和阴性FC，以阐明协同和抑制相互作用。虽然REW和EMO在年龄上主要表现出二次FC变化，表明奖励敏感性降低和风险规避，但COG表现出线性和二次FC变化，表明认知能力的成熟延长和自上而下的调节降低。在中央前回和上级内侧前额叶皮层中发现了额外的年龄×性别效应，这可能分别与男孩和女孩的冒险行为和情绪失调有关。这些结果提供了网络证据，证实了“三元模型”和深化现有的见解与青少年行为的神经发育机制。
Adolescence represents a transitional stage with increased risk taking and mood dysregulation. These vulnerabilities are accountable by developmental dynamics in the triadic functional brain networks underlying reward seeking (REW), emotional avoidance (EMO), and cognitive regulation (COG). However, these triadic dynamics, though conceptually established, have yet been investigated directly. Capitalizing on public database of resting-state fMRI from 222 adolescents (8–18 years old, 89F133M), this study examined cross-sectional development profiles of functional connectivity (FC) by jointly considering bilateral seeds of the ventral striatum, amygdala, and dorsal lateral prefrontal cortex in probing the networks of REW, EMO, and COG, respectively. Positive and negative FCs were considered separately for clarification of synergetic and suppressive interactions. While the REW and EMO mostly exhibited quadratic FC changes across age, suggesting reduced reward sensitivity and risk avoidance, the COG exhibited both linear and quadratic FC changes, suggesting both protracted maturation of cognitive ability and lowered top-down regulation. Additional age × gender effects were identified in the precentral gyrus and superior medial prefrontal cortex, which may associate risky action and emotion dysregulation to boys and girls, respectively. These results provide network evidence in substantiating the “triadic model” and deepening existing insights into neurodevelopmental mechanisms associated with adolescent behavior.
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影响因子：
16.6
作者：
Büchel C;Peters J;Banaschewski T;Bokde AL;Bromberg U;Conrod PJ;Flor H;Papadopoulos D;Garavan H;Gowland P;Heinz A;Walter H;Ittermann B;Mann K;Martinot JL;Paillère-Martinot ML;Nees F;Paus T;Pausova Z;Poustka L;Rietschel M;Robbins TW;Smolka MN;Gallinat J;Schumann G;Knutson B;IMAGEN consortium
通讯作者：
IMAGEN consortium
DOI：
10.1111/j.1532-7795.2010.00712.x
发表时间：
2011-03-01
期刊：
Journal of research on adolescence : the official journal of the Society for Research on Adolescence
影响因子：
--
作者：
Casey B;Jones RM;Somerville LH
通讯作者：
Somerville LH
影响因子：
2.5
作者：
Ernst, Monique
通讯作者：
Ernst, Monique
影响因子：
4.9
作者：
K. Rosch;S. Mostofsky;M. B. Nebel
通讯作者：
K. Rosch;S. Mostofsky;M. B. Nebel
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM