Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation.
Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation.
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DOI：
10.3389/fbioe.2022.837639
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发表时间：
2022
影响因子：
5.7
通讯作者：
El Backly R
中科院分区：
文献类型：
--
作者：
Elnawam H;Abdelmougod M;Mobarak A;Hussein M;Aboualmakarem H;Girgis M;El Backly R
十多年来，再生牙髓手术被描述为治疗未成熟坏死恒牙的范式转变，这是由于它们能够使牙根成熟，随后增强牙齿的抗断裂性，以及重要的根管内组织再生的潜力。与此同时，微创牙髓病学是另一个新兴的概念，主要关注牙齿结构的保护。再生和微创牙髓学都具有保留原始牙齿结构的潜力，可以被认为是两门具有共同目标的革命性科学。实现这一目标不仅需要采用适当的策略来重建理想的再生龛，而且需要修改目前正在再生牙髓病学中实施的现有概念和方案，以解决影响这些程序结果的两个重要挑战;牙齿结构的保护和实现有效的消毒。因此，寻找新的仿生细胞友好的消毒剂和策略是至关重要的，如果这样一个新的集成概念是预见在未来。这可以通过倡导一种新的合并概念“微创再生牙髓手术（MIREPs）”来实现，通过将微创入路腔设计/制备和仿生消毒方案结合起来修改REP的临床方案，这可以提高临床治疗效果，并在未来允许个性化的消毒/再生方案，以进一步优化MIREPs的结果。在这篇综述中，我们的目的是介绍这个新的概念，它的实现和挑战沿着未来的前景，临床实施。
Regenerative endodontic procedures have been described for over a decade as a paradigm shift in the treatment of immature necrotic permanent teeth, owing to their ability to allow root maturation with subsequent enhancement of the tooth’s fracture resistance in addition to the potential for regeneration of vital intracanal tissues. Concomitantly, minimally invasive endodontics is another rising concept with the main concern of preservation of tooth structure. Stemming from their potential to preserve the original tooth structure, both regenerative and minimally invasive endodontics could be considered as two revolutionary sciences with one common goal. Achieving this goal would entail not only employing the appropriate strategies to recreate the ideal regenerative niche but modifying existing concepts and protocols currently being implemented in regenerative endodontics to address two important challenges affecting the outcome of these procedures; conservation of tooth structure and achieving effective disinfection. Therefore, the search for new biomimetic cell-friendly disinfecting agents and strategies is crucial if such a novel integratory concept is to be foreseen in the future. This could be attainable by advocating a new merged concept of “minimally invasive regenerative endodontic procedures (MIREPs),” through modifying the clinical protocol of REPs by incorporating a minimally invasive access cavity design/preparation and biomimetic disinfection protocol, which could enhance clinical treatment outcomes and in the future; allow for personalized disinfection/regeneration protocols to further optimize the outcomes of MIREPs. In this review, we aim to introduce this new concept, its realization and challenges along with future perspectives for clinical implementation.
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影响因子：
4.2
作者：
Albuquerque MTP;Nagata J;Bottino MC
通讯作者：
Bottino MC
影响因子：
4.2
作者：
Cerqueira-Neto, Ana Carolina C. L.;Prado, Marina C.;de-Jesus-Soares, Adriana
通讯作者：
de-Jesus-Soares, Adriana
DOI：
10.4103/2231-0762.200710
发表时间：
2017-01
影响因子：
1.1
作者：
Bohora A;Kokate S
通讯作者：
Kokate S
DOI：
10.1002/jbm.b.34250
发表时间：
2019-07
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
--
作者：
Bottino MC;Albuquerque MTP;Azabi A;Münchow EA;Spolnik KJ;Nör JE;Edwards PC
通讯作者：
Edwards PC
影响因子：
4.2
作者：
Aksel, Hacer;Albanyan, Hajar;Azim, Adham A.
通讯作者：
Azim, Adham A.