Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans.
Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans.
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DOI：
10.1016/j.vaccine.2010.12.029
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发表时间：
2011-03-03
期刊：
影响因子：
5.5
通讯作者：
McElhaney, Janet E.
中科院分区：
文献类型：
--
作者：
Zhou, Xin;McElhaney, Janet E.
关键词：
细胞免疫应答的年龄依赖性变化主要发生在CD8+ T细胞中，CD4+ T细胞相对较少。我们发现，与年轻人相比，在老年人中，效应记忆和效应CD8+ t细胞亚群对流感A/H3N2攻击的反应降低了细胞溶解活性。相比之下，老年人中的效应CD4+ t细胞亚群与年轻人具有相似的表型和功能特征。此外，我们观察到与接种季节性流感疫苗的年轻人相比，老年人对季节性流感a /H3N2和大流行性H1N1 （pH1N1）毒株的细胞溶解t细胞反应减弱。这些结果与在不同年龄组中观察到的季节性和大流行性流感感染的严重并发症发生率一致，并表明当CD8+ T细胞在衰老过程中受损时，CD4+ T细胞可能对流感感染提供代偿反应。
Age-dependent changes in the cellular immune response have been mainly described in CD8+ T cells, with relative sparing of CD4+ T cells. We show that in older compared to young adults, effector memory and effector CD8+ T-cell subsets responding to influenza A/H3N2 challenge have diminished cytolytic activity. In contrast, effector CD4+ T-cell subsets in older adults share similar phenotypic and functional characteristics with those from young adults. Further, we observed a diminished cytolytic T-cell response to both seasonal influenza A/H3N2 and pandemic H1N1 (pH1N1) strains in older compared to young adults who had received seasonal influenza vaccine. These results are consistent with the observed rates of serious complications from seasonal and pandemic influenza infections in different age groups, and suggest that CD4+ T cells may provide a compensatory response to influenza infection when CD8+ T cells become compromised during the aging process.
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影响因子：
5.5
作者：
McElhaney, Janet E.;Ewen, Catherine;Bleackley, R. Chris
通讯作者：
Bleackley, R. Chris
DOI：
10.1084/jem.20032083
发表时间：
2004-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Combadiere B;Boissonnas A;Carcelain G;Lefranc E;Samri A;Bricaire F;Debre P;Autran B
通讯作者：
Autran B
DOI：
10.1073/pnas.0538056100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Johnson, BJ;Costelloe, EO;Kelso, A
通讯作者：
Kelso, A
影响因子：
6.4
作者：
Powers, DC;McElhaney, JE;Wilkinson, BE
通讯作者：
Wilkinson, BE
影响因子：
15.3
作者：
Casazza, Joseph P.;Betts, Michael R.;Price, David A.;Precopio, Melissa L.;Ruff, Laura E.;Brenchley, Jason M.;Hill, Brenna J.;Roederer, Mario;Douek, Daniel C.;Koup, Richard A.
通讯作者：
Koup, Richard A.