Non-exercise estimated cardiorespiratory fitness and cancer incidence: The NIH-AARP diet and health study.
Non-exercise estimated cardiorespiratory fitness and cancer incidence: The NIH-AARP diet and health study.
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DOI：
10.1016/j.jshs.2023.02.004
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发表时间：
2023-11
影响因子：
11.7
通讯作者：
Matthews CE
中科院分区：
文献类型：
--
作者：
Vainshelboim B;Myers J;Matthews CE
在男性和女性中，较高的非运动估计心肺适能（NEE-CRF）与较低的癌症总发病率相关。较高的NEE-CRF与较低的男性结直肠癌发病率和较低的女性乳腺癌发病率相关。这些新发现表明，较高的健康水平可能对预防癌症的发展有好处，而较低的健康水平可能是一个可改变的癌症风险因素。非运动估计心肺适能（NEE-CRF）已被证明与死亡率相关，尽管其与癌症发病率的关系尚不清楚。该研究旨在评估NEE-CRF与大量男性和女性癌症发病率之间的前瞻性关联。美国国立卫生研究院退休人员饮食与健康研究是一项前瞻性队列研究，包括402,548名年龄在50-71岁、基线（1995-1996）无癌症的参与者(男性（n = 238,835）和女性（n = 163,713），随访至2015年12月31日。暴露变量是以代谢当量表达的NEE-CRF。NEE-CRF的估计使用了来自基线问卷的人口统计和生活方式行为的自我报告预测因子的有效方程。主要结局是总癌症发病率和前列腺癌、乳腺癌、肺癌和结直肠癌的发病率。对Cox比例风险模型进行分析，以确定NEE-CRF与确定的癌症危险因素调整后的癌症发病率结局之间的关系。在13.7±3.2年的随访期间（平均±SD）， 64,344名男性和31,315名女性发生了新的癌症。NEE-CRF每增加1个代谢当量，男性总发病率和结直肠癌发病率的风险比和95%置信区间（95% ci）分别为0.96 （95% ci: 0.94 - 0.97）和0.88 (95% ci: 0.84-0.92)，女性总发病率和乳腺癌发病率分别为0.95 （95% ci: 0.93-0.97）和0.94 (95% ci: 0.91-0.97)（均p < 0.001）。NEE-CRF与男性前列腺癌和肺癌的发病率或女性结直肠癌和肺癌的发病率无关。这些结果表明，通过应用非运动估计方法评估的较高CRF水平可能提供预防癌症发展的益处，而低CRF可能作为可改变的癌症风险因素。将NEE-CRF整合到筛查范式中，并参考低健康个体来提高CRF，可以补充癌症公共卫生预防策略。
Higher non-exercise estimated cardiorespiratory fitness (NEE-CRF) was associated with lower risk of total cancer incidence in men and women. Higher NEE-CRF was associated with lower risk of colorectal cancer incidence in men and lower risk of breast cancer incidence in women. These novel findings suggest that higher fitness levels may provide preventive benefits against the development of cancer, while low fitness could potentially serve as a modifiable cancer risk factor. Non-exercise estimated cardiorespiratory fitness (NEE-CRF) has been shown to be associated with mortality, although its association with cancer incidence is unknown. The study aimed to assess the prospective association between NEE-CRF and cancer incidence in a large cohort of men and women. The National Institutes of Health-American Association of Retired Persons diet and health study is a prospective cohort that included 402,548 participants aged 50–71 years who were free from cancer at baseline (1995–1996) (men (n = 238,835) and women (n = 163,713)) and were followed until December 31, 2015. The exposure variable was NEE-CRF expressed in metabolic equivalents. NEE-CRF was estimated using a validated equation of self-reported predictors on demographics and lifestyle behaviors derived from baseline questionnaires. Primary outcomes were total cancer incidence and incidence of prostate, breast, lung, and colorectal cancers. Cox proportional hazards models were analyzed for the association between NEE-CRF and cancer incidence outcomes adjusted for established cancer risk factors. During 13.7 ± 3.2 years of follow-up (mean ± SD), 64,344 men and 31,315 women developed a new cancer. For every 1-metabolic equivalent higher NEE-CRF, the hazard ratios and 95% confidence intervals (95%CIs) were 0.96 (95%CI: 0.94–0.97) and 0.88 (95%CI: 0.84–0.92) of total and colorectal cancer incidence among men, and 0.95 (95%CI: 0.93–0.97) and 0.94 (95%CI: 0.91–0.97) of total and breast cancer incidence among women, respectively (all p < 0.001). NEE-CRF was not associated with incidence of prostate and lung cancers in men or colorectal and lung cancers in women. These results suggest that higher CRF levels, as assessed by the applied non-exercise estimated method, may provide preventive benefits against the development of cancer, while low CRF could potentially serve as a modifiable cancer risk factor. Integrating NEE-CRF into screening paradigms and referring low-fit individuals to improve CRF could complement the public health prevention strategy against cancer.
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影响因子：
3.7
作者：
Anand, Preetha;Kunnumakara, Ajaikumar B.;Sundaram, Chitra;Harikumar, Kuzhuvelil B.;Tharakan, Sheeja T.;Lai, Oiki S.;Sung, Bokyung;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
休闲时间体力活动与癌症风险：基于 126 项高质量流行病学研究对世界卫生组织建议的评估
影响因子：
18.4
作者：
Liu, Li;Shi, Yun;Wei, Sheng
通讯作者：
Wei, Sheng
DOI：
10.1097/00005768-199903000-00019
发表时间：
1999-03-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Matthews, CE;Heil, DP;Pastides, H
通讯作者：
Pastides, H
影响因子：
24
作者：
Artero, Enrique G.;Jackson, Andrew S.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
5.8
作者：
Brown JC;Winters-Stone K;Lee A;Schmitz KH
通讯作者：
Schmitz KH