Folic Acid Has a Protective Effect on Retinal Vascular Endothelial Cells against High Glucose.
Folic Acid Has a Protective Effect on Retinal Vascular Endothelial Cells against High Glucose.
复制标题
叶酸对视网膜血管内皮细胞对抗高血糖具有保护作用
DOI：
10.3390/molecules23092326
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发表时间：
2018-09-12
期刊：
影响因子：
--
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Wang Z;Xing W;Song Y;Li H;Liu Y;Wang Y;Li C;Wang Y;Wu Y;Han J
糖尿病视网膜病变（DR）是糖尿病的严重并发症，严重影响患者的生活质量。由于DR造成的损害，迫切需要开发有效的药物。叶酸是一种水溶性维生素，是维生素B群之一。叶酸广泛存在于肉类和蔬菜中。临床上，体内叶酸水平低可能与DR有一定的相关性。但目前尚无相关基础研究证明叶酸水平与DR之间的关系。因此，本研究的目的是探讨叶酸是否对视网膜血管内皮细胞针对高血糖水平具有保护作用。此外，还进一步探讨了叶酸作用的分子机制。结果显示，与高糖组相比，叶酸显着抑制细胞活力、管长度、迁移细胞和BrdU+细胞百分比。此外，叶酸降低了TEAD1的mRNA表达以及TEAD1和YAP1的蛋白表达。这些发现表明，叶酸可以通过调节 Hippo 信号通路中的蛋白质来保护视网膜血管内皮细胞免受高糖诱导的损伤。
Diabetic retinopathy (DR) is a severe complication of diabetes, which seriously affects the life quality of patients. Because of the damage caused by DR, there is an urgent need to develop effective drugs. Folic acid, a water-soluble vitamin, is one of the vitamin B complexes. Folic acid is widely found in the meat and vegetables. In the clinic, low folic acid levels in the body may have a certain correlation with DR. However, there is no relevant basic research proving a relationship between folic acid levels and DR. The purpose of this study was therefore to investigate whether folic acid has a protective effect on the retinal vascular endothelial cells against high glucose levels. Moreover, the molecular mechanism of action of folic acid was further explored. The results showed that folic acid significantly suppressed the cell viability, tube length, migrated cells and the percentage of BrdU+ cells compared with the high glucose group. Moreover, folic acid decreased the mRNA expression of TEAD1 and the protein expression of TEAD1 and YAP1. These findings indicate that folic acid can protect retinal vascular endothelial cells from high glucose-induced injury by regulating the proteins in the Hippo signaling pathway.
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发表时间：
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