Electrically stimulated cell migration and its contribution to wound healing.
Electrically stimulated cell migration and its contribution to wound healing.
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DOI：
10.1186/s41038-018-0123-2
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发表时间：
2018
期刊：
影响因子：
5.3
通讯作者：
Zhao M
中科院分区：
文献类型：
--
作者：
Tai G;Tai M;Zhao M
自然产生的电场被认为是形态发生的线索，并与整个哺乳动物和两栖动物以及植物王国的生长和愈合有关。动物身上的电是在世纪发现的。电场激活多种细胞信号通路，如PI 3 K/PTEN、KCNJ 15/Kir4.2的膜通道和细胞内多胺。这些通路参与生理电场、定向细胞迁移（趋电性，也称为趋电性）以及可能的其他细胞反应的感测。重要的是，电场提供了主导和压倒性的信号，指导细胞迁移。电刺激在促进伤口愈合和激活慢性和不愈合伤口的再生方面可能是一种很有前途的治疗方法。本文综述了电场的生理作用，其细胞和分子机制，其潜在的治疗价值，以及仍然有待回答的问题。
Naturally occurring electric fields are known to be morphogenetic cues and associated with growth and healing throughout mammalian and amphibian animals and the plant kingdom. Electricity in animals was discovered in the eighteenth century. Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses. Importantly, electric fields provide a dominant and over-riding signal that directs cell migration. Electrical stimulation could be a promising therapeutic method in promoting wound healing and activating regeneration of chronic and non-healing wounds. This review provides an update of the physiological role of electric fields, its cellular and molecular mechanisms, its potential therapeutic value, and questions that still await answers.
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