Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice.
Involvement of oxidative stress and inflammation in liver injury caused by perfluorooctanoic acid exposure in mice.
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氧化应激和炎症与全氟辛酸暴露引起的小鼠肝损伤的关系
DOI：
10.1155/2014/409837
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发表时间：
2014
影响因子：
--
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Yang B;Zou W;Hu Z;Liu F;Zhou L;Yang S;Kuang H;Wu L;Wei J;Wang J;Zou T;Zhang D
全氟辛酸（PFOA）广泛存在于环境中，据报道可引起动物和人类的肝毒性。在这项研究中，小鼠口服不同浓度的PFOA（2.5、5或10 mg/kg/天）。组织学检查显示，连续14 d暴露于PFOA导致严重的肝细胞损伤和明显的炎性细胞浸润。此外，丙二醛的形成和过氧化氢的产生，氧化应激的指标，显着诱导PFOA治疗小鼠的肝脏。此外，小鼠暴露于PFOA后，肝脏中的白细胞介素-6、环氧合酶-2和C反应蛋白（炎症反应的标志物）水平显著升高。这些结果表明，PFOA诱导的肝脏毒性可能与小鼠的氧化应激和炎症反应有关。
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin‐6, cyclooxygenase‐2, and C‐reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA‐induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
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