Hepatitis virus capsid polymorph stability depends on encapsulated cargo size.

Hepatitis virus capsid polymorph stability depends on encapsulated cargo size.
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DOI:
10.1021/nn4017839
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发表时间:
2013-10-22
期刊:
影响因子:
17.1
通讯作者:
Dragnea B
Dragnea B
中科院分区:
材料科学1区
文献类型:
--
作者:
He L;Porterfield Z;van der Schoot P;Zlotnick A;Dragnea B

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采用乙型肝炎病毒样颗粒的模板组装方法来确定乙型肝炎病毒(HBV)二十面体核心的T = 3和T = 4多态性如何响应被封装货物大小的系统,逐渐变化。研究发现,尽管协同程度不同,但在不同的核心直径周围,组装成完整的病毒样颗粒是协同发生的。在这些类病毒颗粒中,发现外径与T = 4相似的颗粒能够容纳最大范围的货物尺寸。
A templated assembly approach for Hepatitis B virus-like particles was employed to determine how the T = 3 and T = 4 polymorphs of the Hepatitis B virus (HBV) icosahedral cores respond to a systematic, gradual change in the encapsulated cargo size. It was found that assembly into complete virus-like particles occurs cooperatively around a variety of core diameters, albeit the degree of cooperativity varies. Among these virus-like particles, it was found that those of an outer diameter similar to T = 4 are able to accommodate the widest range of cargo sizes.
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