Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron.
Non-Transferrin-Bound Iron in the Spotlight: Novel Mechanistic Insights into the Vasculotoxic and Atherosclerotic Effect of Iron.
复制标题
聚光灯下的非转铁蛋白结合铁：铁的血管毒性和动脉粥样硬化作用的新机制见解。
DOI：
10.1089/ars.2020.8167
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发表时间：
2021-08-20
影响因子：
6.6
通讯作者：
Vinchi F
中科院分区：
文献类型：
--
作者：
Vinchi F
意义：在许多国家，动脉粥样硬化几乎是衰老、饮食偏好、缺乏锻炼和其他生活方式的必然结果，但识别新的风险因素对于解决这一疾病越来越重要，这已成为数十亿人的主要健康负担。长期以来，人们一直怀疑铁会促进动脉粥样硬化的发展，但数据相互矛盾，铁的作用仍然存在争议。最近的进展：关于这个长期存在争议的问题，最近发表了几项实验和临床研究，强调了解开这个话题背后复杂性的迫切需要。关键问题：当前综述的目的是概述目前关于铁对动脉粥样硬化的影响的知识，并讨论非转铁蛋白结合铁（NTBI）作为血管毒性和动脉粥样硬化驱动因素的新作用。最后，我将提供铁加剧动脉粥样硬化的细胞过程和分子途径的详细机制见解。总的来说，这篇综述强调了一个复杂的框架，其中NTBI在动脉粥样硬化中通过以促动脉粥样硬化和促炎症的方式改变血清和血管微环境，影响血管细胞的功能和存活，促进泡沫细胞形成，诱导血管生成，钙化和斑块不稳定，在多个层面上起作用。未来方向：使用额外的铁标志物（例如，NTBI）可能有助于充分预测心血管疾病的易感性。需要在老年人群中进行临床研究，以解决生理范围内铁波动的致动脉粥样硬化作用以及铁限制方法的治疗价值。Antioxid。氧化还原信号，35,387-414。
Significance: While atherosclerosis is an almost inevitable consequence of aging, food preferences, lack of exercise, and other aspects of the lifestyle in many countries, the identification of new risk factors is of increasing importance to tackle a disease, which has become a major health burden for billions of people. Iron has long been suspected to promote the development of atherosclerosis, but data have been conflicting, and the contribution of iron is still debated controversially. Recent Advances: Several experimental and clinical studies have been recently published about this longstanding controversial problem, highlighting the critical need to unravel the complexity behind this topic. Critical Issues: The aim of the current review is to provide an overview of the current knowledge about the proatherosclerotic impact of iron, and discuss the emerging role of non-transferrin-bound iron (NTBI) as driver of vasculotoxicity and atherosclerosis. Finally, I will provide detailed mechanistic insights on the cellular processes and molecular pathways underlying iron-exacerbated atherosclerosis. Overall, this review highlights a complex framework where NTBI acts at multiple levels in atherosclerosis by altering the serum and vascular microenvironment in a proatherogenic and proinflammatory manner, affecting the functionality and survival of vascular cells, promoting foam cell formation and inducing angiogenesis, calcification, and plaque destabilization. Future Directions: The use of additional iron markers (e.g., NTBI) may help adequately predict predisposition to cardiovascular disease. Clinical studies are needed in the aging population to address the atherogenic role of iron fluctuations within physiological limits and the therapeutic value of iron restriction approaches. Antioxid. Redox Signal. 35, 387–414.
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影响因子：
5.8
作者：
Bandyopadhyay, Amitabha;Yadav, Prem Swaroop;Prashar, Paritosh
通讯作者：
Prashar, Paritosh
影响因子：
3
作者：
Aljwaid, Husam;White, Desley L.;Pinkney, Jonathan H.
通讯作者：
Pinkney, Jonathan H.
DOI：
10.1111/j.1751-553x.2006.00862.x
发表时间：
2007-06-01
影响因子：
3
作者：
Amendola, G.;Danise, P.;Di Concilio, R.
通讯作者：
Di Concilio, R.
影响因子：
5.3
作者：
Becs G;Zarjou A;Agarwal A;Kovács KÉ;Becs Á;Nyitrai M;Balogh E;Bányai E;Eaton JW;Arosio P;Poli M;Jeney V;Balla J;Balla G
通讯作者：
Balla G
影响因子：
1
作者：
Boudrahem-Addour, Nassima;Izem-Meziane, Malika;Djerdjouri, Bahia
通讯作者：
Djerdjouri, Bahia