The Issue of Tissue: Approaches and Challenges to the Light Control of Drug Activity: A Mini-Review.
The Issue of Tissue: Approaches and Challenges to the Light Control of Drug Activity: A Mini-Review.
复制标题
组织问题：药物活性光控制的方法和挑战：小型审查。
作者：
通过将药物作用与光照射联系起来，可以解决与药物输送相关的许多主要挑战。这些挑战包括药物活性的间隔、时间和数量。一旦药物的活性与光联系起来，这种活性就可以更容易地被操纵，因为光本身很容易操纵。光控制可以解决的主要问题之一是脱靶毒性。如果仅使用光在靶组织中激活药物，则这可能会受到限制。对于一天中需要不同浓度的药物，不同的光有可能暂时调节药物的释放。由于这些和其他优点，已经开发了一系列利用光来操纵药物活性的机制，包括光裂解控制、光构象控制、光热控制和光降解控制。光控制的这些主要主题将在这篇小评论中进行描述，并举例说明。此外，还将描述和分析组织光介电常数问题，这可以说是该学科的主要挑战。
Many of the major challenges associated with drug delivery can potentially be addressed by linking drug action to light irradiation. These challenges include the spacing, timing and amount of a drug's activity. Once a drug's activity is linked to light, this activity can be more easily manipulated, because light itself is easy to manipulate. One of the main issues that light control can address is off‐target toxicity. This has the potential to be limited if drugs are activated only in target tissues using light. For drugs that are needed at varying concentrations through the day, varying light has the potential to temporally modulate drug release. Because of these and other advantages, a range of mechanisms for using light to manipulate drug activity has been developed, including photocleavage control, photoconformational control, photothermal control and photodegradation control. These major themes of light control will be described in this minireview, and illustrated with examples. In addition, the issue of tissue light permittivity, arguably the major challenge for the discipline, will be described and analyzed.
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DOI：
10.1073/pnas.1713137114
发表时间：
2017-11-21
影响因子：
11.1
作者：
Goodman, Amanda M.;Neumann, Oara;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
影响因子：
14.9
作者：
Chaulk, SG;MacMillan, AM
通讯作者：
MacMillan, AM
紫外线和近红外线触发聚合物纳米颗粒的释放。
影响因子：
15
作者：
Fomina, Nadezda;McFearin, Cathryn;Sermsakdi, Marleen;Edigin, Osayimwense;Almutairi, Adah
通讯作者：
Almutairi, Adah
影响因子：
4.9
作者：
Bio, Moses;Nkepang, Gregory;You, Youngjae
通讯作者：
You, Youngjae
影响因子：
3.5
作者：
Bashkatov, Alexey N.;Berezin, Kirill V.;Tuchin, Valery V.
通讯作者：
Tuchin, Valery V.