Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa.
Implications of starvation-induced change in right dorsal anterior cingulate volume in anorexia nervosa.
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DOI：
10.1002/eat.20549
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发表时间：
2008-11
影响因子：
5.5
通讯作者：
Andreasen, Nancy
中科院分区：
文献类型：
--
作者：
McCormick, Laurie M.;Keel, Pamela K.;Brumm, Michael C.;Bowers, Wayne;Swayze, Victor;Andersen, Arnold;Andreasen, Nancy
关键词：
越来越多的证据表明，扣带回前皮质(ACC)在神经性厌食症(AN)的病理生理学中起着重要作用。这项研究试图确定活动的AN中的ACC体积是否受到饥饿的影响，如果是的话，这是否具有临床意义。18例活动期AN患者和年龄、性别匹配的正常对照组接受了磁共振成像(MRI)检查。16例AN患者(%)在进食时进行了智商(IQ)测试，14例(78%)在体重归一化后进行了重复磁共振检查，10例(56%)在住院后1年有结果数据。活动期AN患者右侧背侧ACC体积较对照组显著减少，且与操作智商降低有关。虽然随着体重的恢复，ACC正常化，但右侧背侧ACC体积的较小变化预示着治疗后的复发。活动AN时右侧背侧ACC体积的减少与知觉组织和概念推理的缺陷有关。治疗期间右侧背侧ACC正常化程度与治疗结果有关。
Converging evidence suggests a role for the anterior cingulate cortex (ACC) in the pathophysiology of anorexia nervosa (AN). This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance. Eighteen patients with active AN and age- and gender-matched normal controls underwent magnetic resonance imaging (MRI). Sixteen patients (89%) with AN had intelligence quotients (IQ) testing at intake, 14 (78%) had repeat MRIs after weight normalization, and 10 (56%) had outcome data at 1-year post-hospitalization. Right dorsal ACC volume was significantly reduced in active AN patients versus controls and was correlated with lower performance IQ. While ACC normalization occurred with weight restoration, smaller change in right dorsal ACC volume prospectively predicted relapse after treatment. Reduced right dorsal ACC volume during active AN relates to deficits in perceptual organization and conceptual reasoning. The degree of right dorsal ACC normalization during treatment is related to outcome.
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影响因子：
5.7
作者：
Magnotta, VA;Harris, G;Heckel, D
通讯作者：
Heckel, D
影响因子：
5.1
作者：
Katzman, DK;Lambe, EK;Zipursky, RB
通讯作者：
Zipursky, RB
影响因子：
3.3
作者：
DILL, DB;SOHOLT, LF;MORRIS, JD
通讯作者：
MORRIS, JD
影响因子：
3.3
作者：
Gündel, H;López-Sala, A;Pujol, J
通讯作者：
Pujol, J
DOI：
10.1111/j.1749-6632.2001.tb03476.x
发表时间：
2001-01-01
期刊：
UNITY OF KNOWLEDGE: THE CONVERGENCE OF NATURAL AND HUMAN SCIENCE
影响因子：
--
作者：
Allman, JM;Hakeem, A;Hof, P
通讯作者：
Hof, P