Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
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DOI：
10.3389/fphys.2014.00037
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发表时间：
2014
影响因子：
4
通讯作者：
Brotto M
中科院分区：
文献类型：
--
作者：
Manring H;Abreu E;Brotto L;Weisleder N;Brotto M
过去十年的研究加强了对骨骼肌的理解，即从体积的角度来看，骨骼肌不仅是身体的主要组织，而且还作为一种主要的调节器，有助于实现最佳的有机体健康。这些对现有知识体系的新贡献引发了人们对骨骼肌收缩以外的作用的极大兴趣。世界卫生组织最近通过其全球疾病负担（GBD）报告，进一步提高了对骨骼肌关键重要性的认识，因为GBD报告称肌肉骨骼（MSK）疾病已成为第二大残疾原因，地球仪上有超过17亿人受到各种肌肉骨骼疾病的影响。除了在MSK疾病中的作用外，骨骼肌也被视为主要的代谢器官，对代谢紊乱，特别是与身体活动不足有关的代谢紊乱有重要贡献。在这篇综述中，我们重点关注了新基因/蛋白质的独特功能（即，MTMR 14，MG 29，sarcalumenin，KLF 15），在过去的几年里，它们帮助提供了关于健康和疾病中肌肉功能，肌肉疲劳，肌肉代谢和肌肉衰老的新见解。接下来，我们深入讨论了这些基因/蛋白质如何汇聚成一个共同的功能，作为细胞内钙稳态的调节剂。建立了钙稳态失调之间的明确联系，并分析了钙库操纵的钙进入的特殊作用。通过了解骨骼肌兴奋-收缩偶联（ECC）过程中以前未知的调节基因的作用而产生的新知识为治疗MSK疾病、肌肉再生和骨骼肌组织工程带来了令人兴奋的新可能性。未来十年的骨骼肌和MSK研究必将带来成果的应用知识，将有望抵消目前沉重和可悲的负担MSK疾病在这个星球上。
Research over the last decade strengthened the understanding that skeletal muscles are not only the major tissue in the body from a volume point of view but also function as a master regulator contributing to optimal organismal health. These new contributions to the available body of knowledge triggered great interest in the roles of skeletal muscle beyond contraction. The World Health Organization, through its Global Burden of Disease (GBD) report, recently raised further awareness about the key importance of skeletal muscles as the GDB reported musculoskeletal (MSK) diseases have become the second greatest cause of disability, with more than 1.7 billion people in the globe affected by a diversity of MSK conditions. Besides their role in MSK disorders, skeletal muscles are also seen as principal metabolic organs with essential contributions to metabolic disorders, especially those linked to physical inactivity. In this review, we have focused on the unique function of new genes/proteins (i.e., MTMR14, MG29, sarcalumenin, KLF15) that during the last few years have helped provide novel insights about muscle function in health and disease, muscle fatigue, muscle metabolism, and muscle aging. Next, we provide an in depth discussion of how these genes/proteins converge into a common function of acting as regulators of intracellular calcium homeostasis. A clear link between dysfunctional calcium homeostasis is established and the special role of store-operated calcium entry is analyzed. The new knowledge that has been generated by the understanding of the roles of previously unknown modulatory genes of the skeletal muscle excitation-contraction coupling (ECC) process brings exciting new possibilities for treatment of MSK diseases, muscle regeneration, and skeletal muscle tissue engineering. The next decade of skeletal muscle and MSK research is bound to bring to fruition applied knowledge that will hopefully offset the current heavy and sad burden of MSK diseases on the planet.
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影响因子：
4.5
作者：
Dowling, James J.;Vreede, Andrew P.;Low, Sean E.;Gibbs, Elizabeth M.;Kuwada, John Y.;Bonnemann, Carsten G.;Feldman, Eva L.
通讯作者：
Feldman, Eva L.
影响因子：
7.8
作者：
Thomas, L;Betz, H
通讯作者：
Betz, H
DOI：
10.1097/mco.0b013e3282fa17fb
发表时间：
2008-05-01
影响因子：
3.1
作者：
Drummond, Micah J.;Rasmussen, Blake B.
通讯作者：
Rasmussen, Blake B.
DOI：
10.1093/gerona/51a.5.m223
发表时间：
1996-09-01
影响因子：
5.1
作者：
Bortz, WM;Bortz, WM
通讯作者：
Bortz, WM
影响因子：
3.4
作者：
Chawla, Jasvinder
通讯作者：
Chawla, Jasvinder