Sticking to it: phytopathogen effector molecules may converge on evolutionarily conserved host targets in green plants.
Sticking to it: phytopathogen effector molecules may converge on evolutionarily conserved host targets in green plants.
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DOI：
10.1016/j.pbi.2018.04.019
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发表时间：
2018-08
影响因子：
9.5
通讯作者：
Schornack S
中科院分区：
文献类型：
--
作者：
Carella P;Evangelisti E;Schornack S
植物病原体效应子在被子植物中聚集在相似的宿主蛋白上。效应子可以靶向存在于整个绿色植物谱系中的宿主蛋白和过程。苔藓植物模式植物是研究效应-靶点关系的一个很有前途的系统。植物相关微生物分泌破坏宿主细胞机制的效应蛋白，以促进植物组织和细胞的定殖。积累的数据表明，独立进化的效应从细菌，真菌和卵菌病原体可能会收敛于一组类似的宿主蛋白在某些被子植物模型，然而，这个概念是否是相关的整个绿色植物谱系是未知的。在这里，我们探讨了病原体效应分子靶向宿主蛋白质存在于进化上遥远的陆地植物谱系，以促进疾病的想法。我们讨论了植物病原体靶向或整合到被子植物免疫受体的宿主蛋白质可能在绿色植物基因组中发现，从早期分歧的非维管谱系（brabetes）到开花植物（被子植物）。这表明，独立进化的病原体可能通过瞄准陆地植物中存在的“脆弱性”中心来操纵它们的宿主。因此，未来的工作重点是可访问的早期分歧的陆地植物模型系统可能会提供一个有见地的进化背景效应靶点的研究。
Phytopathogen effectors converge on similar sets of host proteins in angiosperms. Effectors may target host proteins and processes present across the green plant lineage. Bryophyte model plants are promising systems to investigate effector–target relationships. Plant-associated microbes secrete effector proteins that subvert host cellular machinery to facilitate the colonization of plant tissues and cells. Accumulating data suggests that independently evolved effectors from bacterial, fungal, and oomycete pathogens may converge on a similar set of host proteins in certain angiosperm models, however, whether this concept is relevant throughout the green plant lineage is unknown. Here, we explore the idea that pathogen effector molecules target host proteins present across evolutionarily distant land plant lineages to promote disease. We discuss that host proteins targeted by phytopathogens or integrated into angiosperm immune receptors are likely found across green plant genomes, from early diverging non-vascular lineages (bryophytes) to flowering plants (angiosperms). This would suggest that independently evolved pathogens might manipulate their hosts by targeting `vulnerability’ hubs that are present across land plants. Future work focusing on accessible early divergent land plant model systems may therefore provide an insightful evolutionary backdrop for effector–target research.
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影响因子：
6.7
作者：
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通讯作者：
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