Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae.
Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae.
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DOI：
10.1038/ncomms2996
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
病原微生物向宿主组织分泌效应蛋白，抑制机体免疫，支持病原菌生长，从而引起植物病害。细菌病原体已经进化出几种不同的分泌系统来靶向效应蛋白，但真菌是否也需要不同的分泌机制尚不清楚，真菌是导致大多数作物物种主要疾病的原因。本文报道稻瘟病菌Magnaporthe oryzae在植物侵染过程中具有两种不同的分泌系统来靶向效应物。传递到宿主细胞中的细胞质效应物，优先在生物营养界面复合体中积累，这是一种与侵入性菌丝相关的新型植物富膜结构。我们表明，生物营养界面复合物与一种涉及外囊成分和Sso1 t-SNARE的新型分泌形式有关。相比之下，从侵入性菌丝分泌到细胞外隔室的效应物遵循传统的分泌途径。我们得出结论，爆炸真菌已经进化出独特的分泌系统，以促进组织入侵。了解真菌病原体如何将蛋白质传递到不同的植物区室对于发展疾病控制至关重要。Giraldo等人证明，稻瘟病菌具有针对活水稻细胞内外隔室的蛋白质的独特分泌系统。
To cause plant diseases, pathogenic micro-organisms secrete effector proteins into host tissue to suppress immunity and support pathogen growth. Bacterial pathogens have evolved several distinct secretion systems to target effector proteins, but whether fungi, which cause the major diseases of most crop species, also require different secretory mechanisms is not known. Here we report that the rice blast fungus Magnaporthe oryzae possesses two distinct secretion systems to target effectors during plant infection. Cytoplasmic effectors, which are delivered into host cells, preferentially accumulate in the biotrophic interfacial complex, a novel plant membrane-rich structure associated with invasive hyphae. We show that the biotrophic interfacial complex is associated with a novel form of secretion involving exocyst components and the Sso1 t-SNARE. By contrast, effectors that are secreted from invasive hyphae into the extracellular compartment follow the conventional secretory pathway. We conclude that the blast fungus has evolved distinct secretion systems to facilitate tissue invasion. Understanding how fungal pathogens deliver proteins to diverse plant compartments is critical for developing disease control. Giraldo et al. demonstrate that the blast fungus possesses distinct secretion systems for proteins targeted to compartments inside or outside living rice cells.
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影响因子：
2
作者：
Bolte, S;Talbot, C;Satiat-Jeunemaitre, B
通讯作者：
Satiat-Jeunemaitre, B
影响因子：
56.9
作者：
Dagdas, Yasin F.;Yoshino, Kae;Talbot, Nicholas J.
通讯作者：
Talbot, Nicholas J.
DOI：
10.1111/j.1600-0854.2012.01353.x
发表时间：
2012-07
期刊：
Traffic (Copenhagen, Denmark)
影响因子：
--
作者：
Heider MR;Munson M
通讯作者：
Munson M
影响因子：
56.9
作者：
de Jonge, Ronnie;van Esse, H. Peter;Thomma, Bart P. H. J.
通讯作者：
Thomma, Bart P. H. J.
影响因子：
3
作者：
Khang, CH;Park, SY;Kang, SC
通讯作者：
Kang, SC