Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda.
Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda.
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DOI：
10.1289/ehp.1103500
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发表时间：
2011-09
影响因子：
10.4
通讯作者：
Hovell MF
中科院分区：
文献类型：
--
作者：
Matt GE;Quintana PJ;Destaillats H;Gundel LA;Sleiman M;Singer BC;Jacob P;Benowitz N;Winickoff JP;Rehan V;Talbot P;Schick S;Samet J;Wang Y;Hang B;Martins-Green M;Pankow JF;Hovell MF
背景资料：关于烟草使用和二手烟暴露对健康的影响有广泛的共识，但关于三手烟的性质和后果存在相当大的模糊性。目的：我们介绍了THS和THS暴露的定义，并回顾了有关成分，室内吸附-解吸动力学和THS转化的最新研究结果; THS在住宅环境中的分布和持久性;暴露途径的影响;潜在的临床意义和健康影响;以及影响和受THS影响的行为和政策问题。讨论内容：烟草烟雾污染物的物理和化学转化发生在从几秒到几个月的时间尺度上，并且包括在某些情况下毒性更大的二次污染物的产生（例如，烟草特有的亚硝胺）。THS在现实生活中的空气、灰尘和表面中持续存在，并且与居住在以前由吸烟者居住的家中的非吸烟者的手上的尼古丁和尿液中的可替宁水平升高有关。关于THS的化学、暴露、毒理学、健康风险和政策影响，还有很多需要了解的。结论：关于THS的现有证据提供了强有力的支持，追求一个纲领性的研究议程，以缩小我们目前对THS的化学，暴露，毒理学和健康影响的理解，以及其行为，经济和社会文化因素和后果的差距。这样一个研究议程是必要的，以阐明THS在现有和未来的烟草控制工作中的作用，以减少吸烟开始和吸烟水平，增加戒烟尝试和持续戒烟，并减少烟草使用对发病率和死亡率的累积影响。
Background: There is broad consensus regarding the health impact of tobacco use and secondhand smoke exposure, yet considerable ambiguity exists about the nature and consequences of thirdhand smoke (THS). Objectives: We introduce definitions of THS and THS exposure and review recent findings about constituents, indoor sorption–desorption dynamics, and transformations of THS; distribution and persistence of THS in residential settings; implications for pathways of exposure; potential clinical significance and health effects; and behavioral and policy issues that affect and are affected by THS. Discussion: Physical and chemical transformations of tobacco smoke pollutants take place over time scales ranging from seconds to months and include the creation of secondary pollutants that in some cases are more toxic (e.g., tobacco-specific nitrosamines). THS persists in real-world residential settings in the air, dust, and surfaces and is associated with elevated levels of nicotine on hands and cotinine in urine of nonsmokers residing in homes previously occupied by smokers. Much still needs to be learned about the chemistry, exposure, toxicology, health risks, and policy implications of THS. Conclusion: The existing evidence on THS provides strong support for pursuing a programmatic research agenda to close gaps in our current understanding of the chemistry, exposure, toxicology, and health effects of THS, as well as its behavioral, economic, and sociocultural considerations and consequences. Such a research agenda is necessary to illuminate the role of THS in existing and future tobacco control efforts to decrease smoking initiation and smoking levels, to increase cessation attempts and sustained cessation, and to reduce the cumulative effects of tobacco use on morbidity and mortality.
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影响因子：
4.9
作者：
Jarvis, J;Seed, MJ;Agius, RM
通讯作者：
Agius, RM
影响因子：
10
作者：
Dworski, R
通讯作者：
Dworski, R
急性颗粒物和臭氧暴露的不良心血管效应：小鼠之间的应变变化。
影响因子：
10.4
作者：
Hamade, Ali K.;Rabold, Rkhard;Tankersley, Clarke G.
通讯作者：
Tankersley, Clarke G.
影响因子：
4.7
作者：
Matt, Georg E.;Quintana, Penelope J. E.;Uribe, Anna
通讯作者：
Uribe, Anna
DOI：
10.1080/00039896.1991.9937435
发表时间：
1991-03-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
HEIN, HO;SUADICANI, P;GYNTELBERG, F
通讯作者：
GYNTELBERG, F