Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study.
Reliability and validity of MRI-based automated volumetry software relative to auto-assisted manual measurement of subcortical structures in HIV-infected patients from a multisite study.
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DOI：
10.1016/j.neuroimage.2010.03.033
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发表时间：
2010-07-15
期刊：
影响因子：
5.7
通讯作者：
Tate, David F.
中科院分区：
文献类型：
--
作者：
Dewey, Jeffrey;Hana, George;Russell, Troy;Price, Jared;McCaffrey, Daniel;Harezlak, Jaroslaw;Sem, Ekta;Anyanwu, Joy C.;Guttmann, Charles R.;Navia, Bradford;Cohen, Ronald;Tate, David F.
对两种广泛使用且已发表大量相关研究的软件包——FreeSurfer和使用统计参数映射的个体脑图谱（IBASPM）的自动体积输出进行了检测，以评估其在测量120名美国国立卫生研究院资助的艾滋病神经影像学联盟（HIVNC）队列中的艾滋病病毒（HIV）感染患者（男性占86.7%，年龄47.3±6.3岁，平均感染HIV时长12.0±6.3年）的基线扫描中的尾状核、壳核、杏仁核和海马体时，相对于自动辅助手动（AAM）追踪（即对自动输出进行手动校正）的准确性和一致性。对数据相对于自动辅助手动追踪的准确性和一致性进行了检测，并通过将自动和AAM体积测量值与HIV进展的相关临床指标相关联来评估结构效度。当对所检测的八个结构中的所有患者的结果进行平均时，FreeSurfer在五个结构中实现了更低的绝对体积差异，在七个结构中具有更高的灵敏度，并且在所有八个结构中具有更高的空间重叠。此外，FreeSurfer的结果在所有测量指标中表现出更小的变异性。两种方法的输出结果与AAM分割数据相比，在与HIV进展的临床指标的相关性上存在差异。总体而言，在HIV患者的皮质下体积测量方面，FreeSurfer被证明更为有效，特别是在像这样的多中心队列研究中。这些发现强调，无论使用何种自动方法，对分割输出进行目视检查以及必要时进行手动校正，对于确保所报告结果的有效性仍然至关重要。
The automated volumetric output of FreeSurfer and Individual Brain Atlases using Statistical Parametric Mapping (IBASPM), two widely used and well published software packages, was examined for accuracy and consistency relative to auto-assisted manual (AAM) tracings (i.e., manual correction of automated output) when measuring the caudate, putamen, amygdala, and hippocampus in the baseline scans of 120 HIV-infected patients (86.7% male, 47.3±6.3 y.o., mean HIV duration 12.0±6.3 years) from the NIH-funded HIV Neuroimaging Consortium (HIVNC) cohort. The data was examined for accuracy and consistency relative to auto-assisted manual tracing, and construct validity was assessed by correlating automated and AAM volumetric measures with relevant clinical measures of HIV progression. When results were averaged across all patients in the eight structures examined, FreeSurfer achieved lower absolute volume difference in five, higher sensitivity in seven, and higher spatial overlap in all eight structures. Additionally, FreeSurfer results exhibited less variability in all measures. Output from both methods identified discrepant correlations with clinical measures of HIV progression relative to AAM segmented data. Overall, FreeSurfer proved more effective in the context of subcortical volumetry in HIV-patients, particularly in a multi-site cohort study such as this. These findings emphasize that regardless of the automated method used, visual inspection of segmentation output, along with manual correction if necessary, remains critical to ensuring the validity of reported results.
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