Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study.
Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study.
复制标题
DOI：
10.1007/s00421-011-2072-3
复制
发表时间：
2012-04
影响因子：
3
通讯作者：
Ferrucci, Luigi
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Cappola, Anne R.;Sun, Kai;Bandinelli, Stefania;Dalal, Mansi;Crasto, Candace;Guralnik, Jack M.;Ferrucci, Luigi
握力是全身肌肉力量的有力指标，也是老年人预后不佳的预测指标。衰老抑制基因klotho编码一种单程跨膜蛋白，作为一种循环激素分泌。在小鼠中，klotho基因的表达中断会导致一种综合征，包括骨骼减少、动脉粥样硬化、骨质疏松症和寿命缩短，反之，klotho基因的过度表达会导致更长的寿命。目的是确定血浆klotho水平是否与人类骨骼肌力量有关。在意大利托斯卡纳的一项基于人群的纵向老龄化研究中，我们测量了804名65岁的成年人的血浆klotho，≥。在阈值为681pg/mL时，握力与血浆Klotho呈正相关。在调整了年龄、性别、教育程度、吸烟、体力活动、认知和慢性病后，血浆血钾(每增加1个标准差)与握力(β=1.2，标准差=0.35，P=0.0009)相关。这些结果表明，血浆klotho较低的老年人骨骼肌力较差。
Handgrip strength is a strong indicator of total body muscle strength and is a predictor of poor outcomes in older adults. The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone. In mice, disruption of klotho expression results in a syndrome that includes sarcopenia, atherosclerosis, osteoporosis, and shortened lifespan, and conversely, overexpression of klotho leads to a greater longevity. The objective was to determine whether plasma klotho levels are related to skeletal muscle strength in humans. We measured plasma klotho in 804 adults, ≥65 years, in the InCHIANTI study, a longitudinal population-based study of aging in Tuscany, Italy. Grip strength was positively correlated with plasma klotho at threshold <681 pg/mL. After adjusting for age, sex, education, smoking, physical activity, cognition, and chronic diseases, plasma klotho (per 1 standard deviation increase) was associated with grip strength (beta = 1.20, standard error = 0.35, P = 0.0009) in adults with plasma klotho <681 pg/mL. These results suggest that older adults with lower plasma klotho have poor skeletal muscle strength.
登录
查看更多内容
影响因子：
120.7
作者：
Rantanen, T;Guralnik, JM;White, L
通讯作者：
White, L
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
DOI：
10.1006/bbrc.1997.8019
发表时间：
1998-01-26
影响因子：
3.1
作者：
Matsumura, Y;Aizawa, H;Nabeshima, Y
通讯作者：
Nabeshima, Y
DOI：
10.1067/mlc.2001.113504
发表时间：
2001-04-01
期刊：
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
影响因子：
--
作者：
Morley, JE;Baumgartner, RN;Nair, KS
通讯作者：
Nair, KS
影响因子：
56.9
作者：
Kurosu, H;Yamamoto, M;Kuro-o, M
通讯作者：
Kuro-o, M