Genetic factors for obesity.
Genetic factors for obesity.
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肥胖的遗传因素。
DOI：
--
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发表时间：
2006
影响因子：
5.4
通讯作者：
Y. Nozawa
中科院分区：
文献类型：
--
作者：
Yoshiji Yamada;Kimihiko Kato;T. Kameyama;K. Yokoi;H. Matsuo;Tomonori Segawa;Sachiro Watanabe;S. Ichihara;H. Yoshida;K. Satoh;Y. Nozawa
本研究的目的是确定基因多态性，以可靠地评估肥胖的遗传因素。研究人群包括3906名无血缘关系的日本人（2286名男性，1620名女性），其中包括1196名肥胖受试者（677名男性，519名女性）（体重指数为>或= 25 kg/m2）和2710名对照组（1609名男性，1101名女性）。采用聚合酶链反应和序列特异性寡核苷酸探针结合悬浮阵列技术，对124个候选基因的147个多态性进行了基因型分析。经年龄、性别、吸烟患病率校正的多变量logistic回归分析显示，GCK的- 30wright曲线箭头A多态性、ACE的- 240wright曲线箭头T多态性、APOC3的- 482wright曲线箭头T多态性与肥胖患病率极显著（P < 0.01）相关，ESR1的- 1989wright曲线箭头G多态性与肥胖患病率几乎显著相关。逐步向前选择过程表明，ACE、GCK和ESR1基因型显著（P < 0.01）且独立影响肥胖患病率。与ACE的AA型、GG的GCK型、TT或TG的GCK型和ESR1的TT或TT型相比，ACE的GG或GCK的GG型和ESR1的TT或TG型的组合基因型的优势比最低，为0.45。ACE、GCK和ESR1的基因型可能被证明是评估肥胖遗传因素的可靠方法。确定这些基因的组合基因型可能有助于个体化预防这种情况。
The purpose of the present study was to identify gene polymorphisms for the reliable assessment of genetic factors for obesity. The study population comprised 3906 unrelated Japanese individuals (2286 men, 1620 women), including 1196 subjects (677 men, 519 women) with obesity (body mass index of > or = 25 kg/m2) and 2710 controls (1609 men, 1101 women). The genotypes for 147 polymorphisms of 124 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. Multivariable logistic regression analysis with adjustment for age, sex, and the prevalence of smoking revealed that the -30Gright curved arrow A polymorphism of GCK, the -240Aright curved arrow T polymorphism of ACE, and the -482Cright curved arrow T polymorphism of APOC3 were significantly (P < 0.01) associated with the prevalence of obesity, and the -1989Tright curved arrow G polymorphism of ESR1 was almost significantly associated. A stepwise forward selection procedure demonstrated that ACE, GCK, and ESR1 genotypes significantly (P < 0.01) and independently affected the prevalence of obesity. Combined genotype analysis for these three polymorphisms yielded a lowest odds ratio of 0.45 for the combined genotypes of AT or TT for ACE, GG for GCK, and GG for ESR1 in comparison with the combined genotypes of AA for ACE, GG for GCK, and TT or TG for ESR1. Genotypes for ACE, GCK, and ESR1 may prove reliable for the assessment of genetic factors for obesity. Determination of the combined genotypes for these genes may contribute to the personalized prevention of this condition.
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影响因子：
9.8
作者：
Feitosa, MF;Borecki, IB;Province, MA
通讯作者：
Province, MA
血管紧张素转换酶基因多态性和肥胖：对三个黑人群体的检查。
DOI：
10.1038/oby.2005.94
发表时间：
2005
期刊：
Obesity research.
影响因子：
--
作者：
Kramer,Holly;Wu,Xiaodong;Kan,Donghui;Luke,Amy;Zhu,Xiaofeng;Adeyemo,Adebowale;McKenzie,Colin;Cooper,Richard
通讯作者：
Cooper,Richard
影响因子：
56.9
作者：
Comuzzie, AG;Allison, DB
通讯作者：
Allison, DB
影响因子：
9.8
作者：
Lee, JH;Reed, DR;Price, RA
通讯作者：
Price, RA