Modulation of motor behavior by the mesencephalic locomotor region.
Modulation of motor behavior by the mesencephalic locomotor region.
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DOI：
10.1016/j.celrep.2021.109594
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发表时间：
2021-08-24
期刊：
影响因子：
8.8
通讯作者：
Mena-Segovia J
中科院分区：
文献类型：
--
作者：
Dautan D;Kovács A;Bayasgalan T;Diaz-Acevedo MA;Pal B;Mena-Segovia J
中脑运动区(MLR)是高阶运动神经元和低阶运动神经元之间的接口。MLR的兴奋模块由桥脑脚核(PPN)和楔状核(CNF)组成，它们的激活被认为可以引起不同的运动方式。然而，连接性和生理特性的差异如何解释它们对运动活动的贡献还不是很清楚。在这里，我们报道了CNF谷氨酸能神经元比PPN神经元具有更多的电生理同质性，并且大多具有短程连接，而PPN谷氨酸能神经元是异质性的，并保持着远程连接，最明显的是与基底节的连接。CNF神经元的光基因激活产生短暂的肌肉激活，驱动非自愿运动活动。相比之下，PPN神经元的激活会导致肌肉张力的长期增加，从而减少运动活动并扰乱步态。我们的结果突出了MLR神经元之间的生物物理和功能属性，支持它们对运动行为的不同贡献。Dautan等人。显示了中脑运动区神经元的连接性和生理特性的关键差异。虽然激活CNF神经元会引起不自主的运动反应，但激活PPN神经元会增加肌肉张力，降低运动活性，这表明PPN编码的准备信号先于运动。
The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), and their activation has been proposed to elicit different modalities of movement. However, how the differences in connectivity and physiological properties explain their contributions to motor activity is not well known. Here we report that CnF glutamatergic neurons are more electrophysiologically homogeneous than PPN neurons and have mostly short-range connectivity, whereas PPN glutamatergic neurons are heterogeneous and maintain long-range connections, most notably with the basal ganglia. Optogenetic activation of CnF neurons produces short-lasting muscle activation, driving involuntary motor activity. In contrast, PPN neuron activation produces long-lasting increases in muscle tone that reduce motor activity and disrupt gait. Our results highlight biophysical and functional attributes among MLR neurons that support their differential contribution to motor behavior. Dautan et al. show key differences in the connectivity and physiological properties of neurons of the mesencephalic locomotor region. Although activation of CnF neurons elicits involuntary locomotor responses, activation of PPN neurons increases muscle tone and reduces motor activity, suggesting that PPN encodes a readiness signal that precedes locomotion.
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