Gender disparities in lung cancer survival from an enriched Florida population-based cancer registry.
Gender disparities in lung cancer survival from an enriched Florida population-based cancer registry.
复制标题
DOI：
10.1016/j.amsu.2020.11.081
复制
发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Koru-Sengul T
中科院分区：
文献类型：
--
作者：
Elkbuli A;Byrne MM;Zhao W;Sutherland M;McKenney M;Godinez Y;Dave DJ;Bouzoubaa L;Koru-Sengul T
先前的研究揭示了肺癌生存率的性别差异，但影响结果的临床/个体变量的综合纳入报道不足。我们利用佛罗里达数据癌症系统 (FCDS) 来检查性别与肺癌生存率之间的关联，同时控制大规模人群的预后变量。利用 FCDS 进行的一项回顾性队列分析，与佛罗里达州卫生保健管理局和美国人口普查局的数据相联系，针对 1996 年至 2007 年诊断为原发性肺癌的患者 (n = 165,465)。主要结果指标包括中位生存时间和死亡率。使用多变量 Cox 回归模型、独立样本 T 检验和描述性统计，显着性定义为 p < 0.05。对 165,465 例病例进行分析，显示 44.3% 为女性，55.7% 为男性。大多数患者是白人/高加索人、男性、中高社会经济地位、居住在城市地区、年龄较大。与男性相比，女性的中位生存期更长（9.6 个月 vs 7.1 个月）。多变量分析表明，在控制社会人口统计学、临床和合并症协变量后，女性的生存率更高。男性的死亡风险高于女性（aHR = 1.17，95% CI 1.14–1.19，p < 0.01）。与社会经济地位较低的人相比，社会经济地位较高的人的生存率更高。在控制协变量后，与男性相比，女性在多个时间范围内的肺癌生存率显着提高。需要采取旨在公共教育和获得高质量医疗保健的干预措施，以改善肺癌生存率方面的社会经济和性别差异。未来的研究应该调查肺癌的性别差异，同时纳入个人的社会经济地位和接受的治疗。在控制协变量后，与男性相比，女性在多个时间范围内的肺癌生存率明显更高。我们研究的观察结果揭示了肺癌总体生存率中潜在的性别差距以及经济差异。这些数据强调了未来预防工作重点关注公共教育和及时获得医疗保健的重要性，以期缩小肺癌的生存差距。
Previous studies have revealed gender disparities in lung cancer survivorship, but comprehensive inclusion of clinical/individual variables which affect outcomes is underreported. We utilized the Florida Data Cancer System (FCDS) to examine associations between gender and lung cancer survivorship while controlling for prognostic variables on a large population-based scale. A retrospective cohort analysis utilizing the FCDS, linked to Florida Agency for Health Care Administration and US Census Bureau tracts for patients diagnosed with primary lung cancer (n = 165,465) from 1996 to 2007. Primary outcome measures included median survival time and mortality. Multivariable Cox regression models, independent sample T-tests, and descriptive statistics were utilized with significance defined as p < 0.05. 165,465 cases were analyzed revealing 44.3% females and 55.7% males. The majority of patients were white/Caucasian, males, middle-high socioeconomic status, lived in urban areas, and geriatric age. Females had longer median survival compared to males (9.6 vs 7.1 months). Multivariable analyses showed that women had better survival after controlling for sociodemographic, clinical, and comorbidity covariates. Males had higher risk of mortality than females (aHR = 1.17, 95%CI 1.14–1.19, p < 0.01). Individuals of higher socioeconomic status experienced greater survivorship compared to those of lower socioeconomic status. Women experienced significantly better survival for lung cancer at multiple time frames after controlling for covariates compared to men. Interventions aimed at public education and access to high-quality healthcare are needed to ameliorate socioeconomic and gender-based disparities in lung cancer survivorship. Future studies should investigate gender differences in lung cancer while incorporating individual socioeconomic status and treatment received. Women have a significantly better survival for lung cancer at multiple time frames after controlling for covariates compared to men. The observations of our study shed light on a potential gender gap as well as economic disparities in overall lung cancer survivorship. This data accentuates the importance of focusing future preventative efforts on public education and the access to prompt healthcare in hopes of narrowing survival disparities in lung cancer.
登录
查看更多内容
DOI：
10.1016/j.jtcvs.2014.03.012
发表时间：
2014-07-01
影响因子：
6
作者：
Tong, Betty C.;Kosinski, Andrzej S.;D'Amico, Thomas A.
通讯作者：
D'Amico, Thomas A.
DOI：
10.1056/nejmoa1715907
发表时间：
2018-05-24
期刊：
The New England journal of medicine
影响因子：
--
作者：
Jemal A;Miller KD;Ma J;Siegel RL;Fedewa SA;Islami F;Devesa SS;Thun MJ
通讯作者：
Thun MJ
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Ward, Elizabeth
通讯作者：
Ward, Elizabeth
影响因子：
3.3
作者：
Said, Rabih;Terjanian, Terenig;Taioli, Emanuela
通讯作者：
Taioli, Emanuela
影响因子：
20.4
作者：
Wakelee, Heather A.;Wang, Wei;Johnson, David H.
通讯作者：
Johnson, David H.