Difference in inflammation, atherosclerosis, and platelet activation between coronary artery aneurysm and coronary artery ectasia.
Difference in inflammation, atherosclerosis, and platelet activation between coronary artery aneurysm and coronary artery ectasia.
复制标题
冠状动脉瘤和冠状动脉扩张之间炎症、动脉粥样硬化和血小板活化的差异
DOI：
10.21037/jtd-20-1579
复制
发表时间：
2020-10
影响因子：
2.5
通讯作者：
Luo Y
中科院分区：
文献类型：
--
作者：
Wei W;Wang X;Huang Z;Li X;Luo Y
背景冠状动脉瘤（CAA）和冠状动脉扩张（CAE）可能是两种不同类型的冠状动脉扩张，病因不明。本研究旨在比较CAA和CAE的差异，探讨CAA和CAE的发病机制及抗血小板治疗的必要性。方法选取2017年9月至2019年7月确诊的CAA、CAE和冠状动脉正常（NCA）患者各100例。所有患者均完成踝臂指数（ABI）、脉搏波频率和颈动脉超声检查;并进行常规血液、血脂和免疫参数检测。停药后1周采血，检测血管炎性指标、血小板活化指标、血栓弹力图、血小板聚集率。采用方差分析和卡方检验或Fisher精确检验进行统计学分析。结果CAE患者核周抗中性粒细胞胞浆抗体（ANCA）、内皮细胞-1、基质金属蛋白酶-9和肿瘤坏死因子-α均显著高于NCA患者，胞浆ANCA显著高于CAA患者（P<0.05）。髓过氧化物酶和生长分化因子-15在CAE组明显高于CAA和NCA组（P<0.05）。CAA和CAE组ABI显著低于NCA组（P<0.05），CAA组低密度脂蛋白/高密度脂蛋白显著高于NCA组（P<0.05），CAA组颈动脉增厚检出率显著高于CAE和NCA组（P<0.05）。CAA组Gensini和SYNTAX评分均显著高于CAE组（P<0.05）。CAA和CAE中CD 62 P和PAC-1的百分比高于NCA（P<0.05）。CAA中花生四烯酸聚集率和CAE中5 '-二磷酸腺苷聚集率显著高于NCA（P<0.05）。CAE组凝血酶形成时间和反应时间显著低于NCA组（P<0.05），α角显著高于NCA组（P <0.05）。结论CAE与炎症密切相关，CAA与动脉粥样硬化密切相关。血小板活化存在于这两种疾病，因此，抗血小板治疗的建议。
Background Coronary artery aneurysm (CAA) and coronary artery ectasia (CAE) may be two different types of coronary artery dilatation with unknown etiology. This study aimed to compare the differences between CAA and CAE and to investigate their pathogenesis and the necessity of antiplatelet therapy. Methods One hundred patients each with confirmed CAA, CAE, and normal coronary artery (NCA) from September 2017 to July 2019 were included. All patients completed examinations of the ankle-brachial index (ABI), pulse wave rate, and carotid ultrasonography; and were tested for routine blood, lipid, and immune parameters. Blood samples were collected 1 week after the withdrawal of antiplatelet drugs, and vascular inflammatory indexes, platelet activation indexes, thromboelastography, and the platelet aggregation rate were measured. Analysis of variance and the chi-square or Fisher exact test were used for statistical analysis. Results The perinuclear anti-neutrophil cytoplasmic antibody (ANCA), endothelial-1, matrix metalloproteinase-9, and tumor necrosis factor-α were significantly higher in CAE than in NCA, while cytoplasmic ANCA was appreciably higher in CAE than in CAA (P<0.05). Myeloperoxidase and growth/differentiation factor-15 were significantly higher in CAE than in CAA and NCA (P<0.05). ABI was significantly lower in CAA and CAE than in NCA (P<0.05), low-density lipoprotein/high-density lipoprotein was significantly higher in CAA than in NCA (P<0.05), and the detection rate of carotid artery thickening was significantly higher in CAA than in CAE and NCA (P<0.05). The Gensini and SYNTAX scores were significantly higher in CAA than in CAE (P<0.05). The percentages of CD62P and PAC-1 were higher in CAA and CAE than in NCA (P<0.05). The arachidonic acid aggregation rate in CAA and adenosine 5'-diphosphate aggregation rate in CAE were significantly higher than in NCA (P<0.05). The values of thrombin formation time and reaction time were significantly lower in CAE than in NCA (P<0.05), and the α angle was significantly higher in CAE than in NCA. Conclusions CAE was closely related to inflammation, whereas CAA was closely related to atherosclerosis. Platelet activation was present in both diseases; therefore, antiplatelet therapy is recommended.
登录
查看更多内容
DOI：
10.5114/kitp.2017.70276
发表时间：
2017-09
期刊：
Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery
影响因子：
--
作者：
Ovalı C;Morrad B
通讯作者：
Morrad B
影响因子：
5.5
作者：
Diaz-Zamudio, Mariana;Bacilio-Perez, Ulises;Kimura-Hayama, Eric T.
通讯作者：
Kimura-Hayama, Eric T.
影响因子：
2.8
作者：
Giannoglou, George D.;Antoniadis, Antonios P.;Louridas, George E.
通讯作者：
Louridas, George E.
影响因子：
5.3
作者：
Celik, Sukru;Erdogan, Turan;Kiris, Abdulkadir
通讯作者：
Kiris, Abdulkadir
影响因子：
3.7
作者：
Collins, Michael J.;Borges, Aidan J.;Butany, Jagdish
通讯作者：
Butany, Jagdish