The role of infection and inflammation in sudden infant death syndrome.

The role of infection and inflammation in sudden infant death syndrome.
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DOI:
10.3109/08923970902814137
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发表时间:
2009
影响因子:
3.3
通讯作者:
Blood-Siegfried J
Blood-Siegfried J
中科院分区:
医学4区
文献类型:
--
作者:
Blood-Siegfried J

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婴儿猝死综合症是发达国家新生儿后期死亡的最常见原因。SIDS的确切原因可能是多因素的,涉及关键发育期,脆弱的婴儿以及一个或多个触发因素。许多SIDS婴儿在死亡前有病毒性疾病史。俯卧睡眠姿势是主要的危险因素之一,可以增加气道温度,以及刺激细菌定植和细菌毒素产生。感染和炎症的标志物经常在尸体解剖中与微生物分离物一起发现沿着。虽然感染和SIDS之间的因果关系还没有定论,但有证据表明,感染性损伤可能是某些婴儿SIDS的触发因素。
Sudden Infant Death Syndrome (SIDS) is the most common cause of post-neonatal mortality in the developed world. The exact cause of SIDS is likely to be multifactorial involving a critical developmental period, a vulnerable infant, and one or more triggers. Many SIDS infants have a history of viral illness preceding death. Prone sleep position, one of the leading risk factors, can increase airway temperature, as well as stimulate bacterial colonization and bacterial toxin production. Markers of infection and inflammation are often found on autopsy along with microbial isolates. Although the causal link between infection and SIDS is not conclusive, there is evidence that an infectious insult could be a likely trigger of SIDS in some infants.
DOI: 10.1111/j.1574-695x.1999.tb01326.x
发表时间: 1999-08-01
影响因子: --
作者:
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