Green tea inhibits Helicobacter growth in vivo and in vitro.
Green tea inhibits Helicobacter growth in vivo and in vitro.
复制标题
绿茶可抑制体内和体外螺杆菌的生长。
DOI：
10.1016/j.ijantimicag.2008.10.032
复制
发表时间：
2009-05
影响因子：
10.8
通讯作者：
Houghton, JeanMarie
中科院分区：
文献类型：
--
作者：
Stoicov, Calin;Saffari, Reza;Houghton, JeanMarie
幽门螺杆菌感染是人类最常见的细菌感染之一，是一种1型致癌物质，也是胃癌最重要的危险因素。幽门螺杆菌的细菌因素、宿主遗传和免疫反应的成分、饮食辅助因素以及导致细菌过度生长的酸分泌减少都被认为是诱发胃癌的重要因素。绿茶中发现的成分已经被证明可以抑制细菌的生长，包括螺杆菌的生长。在本研究中，我们在体外评价了绿茶对猫幽门螺杆菌和幽门螺杆菌的杀菌和/或抑菌作用，并在动物模型上评价了绿茶对幽门螺杆菌诱导的胃炎的影响。我们的数据清楚地表明，绿茶对幽门螺杆菌的生长有深远的影响，重要的是，证明在接触螺杆菌感染之前饮用绿茶可以预防胃粘膜炎症。在过去的几年里，在天然食品化合物及其对各种疾病状态的影响方面的研究得到了越来越多的认可。天然药物中的成分，如绿茶，可以进一步用于预防和治疗人类幽门螺杆菌引起的胃炎。
Helicobacter infection, one of the most common bacterial infections in man worldwide, is a type 1 carcinogen and the most important risk factor for gastric cancer. Helicobacter pylori bacterial factors, components of the host genetics and immune response, dietary cofactors and decreased acid secretion resulting in bacterial overgrowth are all considered important factors for induction of gastric cancer. Components found in green tea have been shown to inhibit bacterial growth, including the growth of Helicobacter spp. In this study, we assessed the bactericidal and/or bacteriostatic effect of green tea against Helicobacter felis and H. pylori in vitro and evaluated the effects of green tea on the development of Helicobacter-induced gastritis in an animal model. Our data clearly demonstrate profound growth effects of green tea against Helicobacter and, importantly, demonstrate that green tea consumption can prevent gastric mucosal inflammation if ingested prior to exposure to Helicobacter infection. Research in the area of natural food compounds and their effects on various disease states has gained increased acceptance in the past several years. Components within natural remedies such as green tea could be further used for prevention and treatment of Helicobacter-induced gastritis in humans.
登录
查看更多内容
影响因子：
2.6
作者：
Yanagawa, Y;Yamamoto, Y;Shimamura, T
通讯作者：
Shimamura, T
影响因子：
3.1
作者：
Houghton, J;Macera-Bloch, LS;Korah, RM
通讯作者：
Korah, RM
影响因子：
3.5
作者：
Tombola, F;Campello, S;Zoratti, M
通讯作者：
Zoratti, M
DOI：
10.1084/jem.20021531
发表时间：
2003-04-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kavermann H;Burns BP;Angermuller K;Odenbreit S;Fischer W;Melchers K;Haas R
通讯作者：
Haas R
影响因子：
29.4
作者：
GRAHAM, DY;MALATY, HM;ADAM, E
通讯作者：
ADAM, E