Reliability of fiber tracking measurements in diffusion tensor imaging for longitudinal study.
Reliability of fiber tracking measurements in diffusion tensor imaging for longitudinal study.
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DOI：
10.1016/j.neuroimage.2009.08.062
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发表时间：
2010-01-15
期刊：
影响因子：
5.7
通讯作者：
Floeter, Mary Kay
中科院分区：
文献类型：
--
作者：
Danielian, Laura E.;Iwata, Nobue K.;Thomasson, David M.;Floeter, Mary Kay
关键词：
在 10 名健康受试者中，使用确定性纤维追踪来定位受运动神经元疾病影响的束，评估扩散特性测量的统计可靠性：皮质脊髓束 (CST)、钩束 (UNC) 和整个胼胝体 (CC)，以及分别的膝部 (GE)、运动 (CCM) 和压部 (SP) 纤维。在每个束内获得分数各向异性 (FA)、平均扩散率 (MD)、轴向扩散率 (λ1)、横向扩散率 (λ⊥) 和含有纤维的体素体积 (VV) 的测量结果。为了评估评估者内部和评估者间的可靠性，两名评估者在每次扫描中进行五次光纤跟踪。扫描-重新扫描和纵向可靠性在四名受试者的子集中进行了评估，这些受试者进行了六次扫描，两组扫描间隔一年，每组三次扫描。使用组内相关系数（ICC）和变异系数（CV）评估重复测量的统计可靠性。使用 kappa (κ) 统计量评估束形状的空间一致性。重复的同扫描纤维跟踪评估显示出良好的几何对齐（评估者内 κ > 0.90，评估者间 κ > 0.76）和可靠的扩散特性测量（评估者内 ICC > 0.92，评估者间 ICC > 0.77）。 FA、MD 和 λ⊥ 在不同日期重复扫描（相隔一年）的可靠性非常高（ICC > 0.8）。 VV 也表现出良好的可靠性，但 CV 更高。我们无法证明 λ1 的再现性。通过对每个时间点多次扫描的测量值进行平均，提高了一年后的纵向可靠性。纤维追踪为白质扩散特性的纵向评估提供了可靠的工具。
The statistical reliability of diffusion property measurements was evaluated in ten healthy subjects using deterministic fiber tracking to localize tracts affected in motor neuron disease: corticospinal tract (CST), uncinate fasciculus (UNC), and the corpus callosum in its entirety (CC), and its genu (GE), motor (CCM), and splenium (SP) fibers separately. Measurements of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ1), transverse diffusivity (λ⊥), and volume of voxels containing fibers (VV) were obtained within each tract. To assess intra-rater and inter-rater reliability, two raters carried out fiber tracking five times on each scan. Scan-rescan and longitudinal reliability were assessed in a subset of four subjects who had six scans, with two sets of three scans separated by one year. The statistical reliability of repeated measurements was evaluated using intra-class correlation coefficients (ICC) and coefficients of variation (CV). Spatial agreement of tract shape was assessed using the kappa (κ) statistic. Repeated same-scan fiber tracking evaluations showed good geometric alignment (intra-rater κ > 0.90, inter-rater κ > 0.76) and reliable diffusion property measurements (intra-rater ICC > 0.92, inter-rater ICC > 0.77). FA, MD, and λ⊥ were highly reliable with repeated scans on different days, up to a year apart (ICC > 0.8). VV also exhibited good reliability, but with higher CVs. We were unable to demonstrate reproducibility of λ1. Longitudinal reliability after one year was improved by averaging measurements from multiple scans at each timepoint. Fiber tracking provides a reliable tool for the longitudinal evaluation of white matter diffusion properties.
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影响因子：
1.3
作者：
Abe, O;Masutani, Y;Ohtomo, K
通讯作者：
Ohtomo, K
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
5.8
作者：
Cassol, E;Ranjeva, JP;Berry, I
通讯作者：
Berry, I
影响因子：
4.6
作者：
Dell'Acqua, Flavio;Rizzo, Giovanna;Fazio, Ferruccio
通讯作者：
Fazio, Ferruccio
影响因子：
9.9
作者：
Iwata, N. K.;Aoki, S.;Ugawa, Y.
通讯作者：
Ugawa, Y.