Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study.
Incidence and Risk Factors of Dry Eye in Children and Adolescents With Diabetes Mellitus: A 3-Year Follow-Up Study.
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DOI：
10.3389/fmed.2021.760006
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zou H
中科院分区：
文献类型：
--
作者：
Chen Z;Xiao Y;Qian Y;Lin Q;Xiang Z;Cui L;Sun J;Li S;Qin X;Yang C;Zou H
目的：探讨儿童糖尿病（DM）干眼症的发生率及其危险因素。研究方法：对上海儿童青少年糖尿病眼（SCADE）研究队列中2018年1月未发生干眼症的DM儿童青少年（年龄：3-14岁）进行3年随访，并于2021年1月复查，计算干眼症的发生率和危险因素。结果：2021年随访了40例儿童和青少年糖尿病患者。其中9人被诊断为干眼症，导致干眼症的3年发病率为22.5%，年平均发病率为7.5%。单因素回归分析证实角膜感觉减退（OR = 25.60; 95%CI = 1.31~501.69; P = 0.03）是干眼症发生的危险因素。DM病程长（OR = 1.80; 95%CI = 0.96~3.38; P = 0.07），眼痛（OR = 12.27，95%CI = 0.65~231.48，P = 0.09），父母干眼症（OR = 15.99，95%CI = 0.76~337.75，P = 0.08）可能干扰干眼症的发生。结论：儿童青少年DM患者干眼症的发生率较高。
Purpose: To investigate the incidence and risk factors of dry eye in children with diabetes mellitus (DM) over a period of 3 years. Methods: Children and adolescents with DM (age: 3–14 years) from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study cohort who did not have dry eye in January 2018 were followed-up for 3 years and re-examined in January 2021, and the incidence rate and risk factors for dry eye were calculated. Results: Forty children and adolescents with DM came for follow-up in 2021. Nine of them were diagnosed with dry eye, resulting in a 3-year incidence rate of 22.5% and an annual mean incidence rate of 7.5% for dry eye. Univariate regression analysis confirmed that decreased corneal sensation (OR [Odds Ratio] = 25.60; 95%CI [Confidence Interval] = 1.31~501.69; P = 0.03) was the risk factor for dry eye incidence. Long course of DM (OR = 1.80; 95%CI = 0.96~3.38; P = 0.07), eye pain (OR = 12.27; 95%CI = 0.65~231.48; P = 0.09), and dry eye in parents (OR = 15.99; 95%CI = 0.76~337.75; P = 0.08) may interfere with the incidence of dry eye in them. Conclusions: The incidence of dry eye in children and adolescents with DM is high.
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影响因子：
2
作者：
Manaviat MR;Rashidi M;Afkhami-Ardekani M;Shoja MR
通讯作者：
Shoja MR
影响因子：
3.1
作者：
Akil H;Buluş AD;Andiran N;Alp MN
通讯作者：
Alp MN
影响因子：
2.8
作者：
Baek, Jiwon;Doh, Sang Hee;Chung, Sung Kun
通讯作者：
Chung, Sung Kun
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.
影响因子：
2
作者：
Lane, Jennifer D.;Krumholz, David M.;Morris, Carol
通讯作者：
Morris, Carol